Publications by authors named "Jamie Williamson"
Many countries show a growing willingness to use militaries in support of global health efforts. This Series paper summarises the varied roles, responsibilities, and approaches of militaries in global health, drawing on examples and case studies across peacetime, conflict, and disaster response environments. Militaries have many capabilities applicable to global health, ranging from research, surveillance, and medical expertise to rapidly deployable, large-scale assets for logistics, transportation, and security.
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- CD4 T cell activation is crucial for immune responses to challenges like pathogens and cancer, but post-transcriptional regulation by RNA-binding proteins (RBPs) is less understood.
- Researchers introduced a model to explore the assembly of splicing factors around U2AF2 in activated human CD4 T cells, using techniques like immunoprecipitation and mass spectrometry to identify RNA/protein interactions.
- The study identified "central" interactome members (CIMs), which interact closely with U2AF2, and "peripheral" interactome members (PIMs), which bind to the same transcripts but do not associate physically with U2AF2, revealing complex interactions that influence T cell activation and cytokine expression.