Publications by authors named "Jamie Schlomann"
Airway epithelia and neutrophils are frequently recruited to release host defense factors in response to a variety of pulmonary pathogens. One abundant product of airway epithelia is palate, lung, nasal epithelium clone (PLUNC), a proposed innate immune protein expressed in submucosal glands and surface airway epithelia. In this study, we report the expression of PLUNC in human neutrophils, a previously unrecognized source of this protein.
View Article and Find Full Text PDFDendritic cells (DC) are professional APC, which activate the adaptive immune response. A Ca2+-calmodulin (CaM)-CaM kinase II (CaMKII) pathway regulates maturation and MHC Class II antigen presentation in human DC. The objective of this study was to characterize the mechanisms by which CaMKII modulates the levels and subcellular distribution of MHC Class II molecules.
View Article and Find Full Text PDFArticle Synopsis
- Mononuclear phagocytes play a vital role in both innate and adaptive immune responses, with the p110alpha isoform of PI-3K being crucial for their regulation.
- Research on human monocytic cells lacking p110alpha showed it is essential for certain types of phagocytosis and oxidative bursts, while other forms of phagocytosis do not rely on it.
- Additionally, p110alpha influences cytokine production, promoting IL-12p40 and IL-6, but inhibiting TNF-alpha and IL-10, highlighting its unique regulatory role among the PI-3K family.