Enhanced oxygen availability and preserved aggregative function in platelet concentrates stored at reduced platelet concentration.

Background: Storage of platelets as platelet concentrates for transfusion is limited to 7 days in the United Kingdom due to deleterious effects on platelet quality and function that occur over time. Oxygen (O) availability and sufficient gaseous exchange are known to be essential in maintaining the viability and function of platelets stored for transfusion. Despite this, there is a paucity of studies undertaking direct measures of O and optimization of conditions throughout storage.

International collaboration between low-middle-income and high-income institutions to improve radiation therapy care delivery.

Introduction: The Philippines is a lower-middle-income island country with over 153 000 new cancer diagnosis each year. Despite many patients needing radiotherapy as part of disease management, there remains limitations to access. Currently, the Philippines has 50 linear accelerator facilities serving a population of 110 million.

Extracellular Vesicles in Atherosclerosis Research.

The methodologies described in this chapter inform on how to incorporate extracellular vesicles (EV) in model systems to investigate their role in the initiation and progression of the atherosclerotic plaque. The section will cover application of EV in coagulation and thrombus formation, monocytic migration, and adhesion to endothelial monolayers. These methodologies can be used with EV isolated from any cell type and under any conditions.