Extended Interval Dosing Natalizumab and impact on neuropsychological deficits in Relapsing-Remitting Multiple Sclerosis.

Cognitive impairment and neuropsychiatric symptoms are frequently reported in Relapsing-Remitting Multiple Sclerosis (RRMS). Natalizumab (NTZ) is usually administered on a 4-weekly Standard Interval Dosing (SID) schedule. However, Extended Interval Dosing (EID) at 6-8 weekly intervals has been proven non-inferior regarding relapse risk, with a lower risk of Progressive Multifocal Leukoencephalopathy (PML).

An evaluation of treatment integrity in a randomized trial of behavioural therapy for low mood in stroke patients with aphasia.

Objective: To assess the treatment integrity of behavioural therapy for low mood in stroke patients with aphasia.

Design: Participants were recruited to a multicentre randomized controlled trial (Communication and Low Mood; CALM trial) comparing behavioural therapy with a usual care control group.

Subjects: Of the 51 participants randomly allocated to receive behavioural therapy, 44 participants completed treatment.

Executive functioning in chronic alcoholism and Korsakoff syndrome.

Korsakoff syndrome (KS) is characterized by dense anterograde and retrograde amnesia. There is often a temporal gradient to the retrograde amnesia, with earlier memories more readily recalled than recent memories. Executive functioning has also been found to be impaired in KS.

Communication and Low Mood (CALM): a randomized controlled trial of behavioural therapy for stroke patients with aphasia.

Objective: The aim was to evaluate behavioural therapy as a treatment for low mood in people with aphasia.

Design: A randomized controlled trial comparing behavioural therapy plus usual care with a usual care control. Potential participants with aphasia after stroke were screened for the presence of low mood.

An interpretative phenomenological analysis of the patient experience of awake craniotomy: brain tumour diagnosis to discharge.

Objectives: Previous research exploring the patient experience of awake craniotomy (AC) has yielded contrasting accounts. The current study aimed to explore the lived experience of having undergone an AC in the United Kingdom.

Design: This was a qualitative, semi-structured interview study.

Egocentric disorientation following bilateral parietal lobe damage.

Aguirre and D'Esposito (1999) suggested a taxonomy and theoretical framework for understanding topographical disorders. One of the problems they described involved egocentric disorientation, in which deficits are not strictly confined to the topographical sphere but are seen on a wide variety of visuo-spatial paradigms. Here, we report a neuropsychological investigation of MU, a person with egocentric disorientation.