Publications by authors named "Jamie L Lombardo"

Background: Characterizing multiple hepatic lesions on cross-sectional imaging, particularly differentiating abscesses from metastatic lesions, can be challenging.

Case Presentation: A male aged 53 years with a history of chromophobe renal cell carcinoma presented with fevers and abdominal pain and was found to have multiple hepatic lesions concerning for hepatic abscesses. The lesions initially evaded diagnosis on imaging, laboratory tests, and biopsy, but ultimately were determined to be a rare case of metastatic chromophobe renal cell carcinoma of the liver.

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  • Type 1 diabetes mellitus (T1DM) is a lifelong condition that leads to the immune system attacking pancreatic beta cells, resulting in high blood sugar levels and symptoms like frequent urination and weight loss; patients require insulin treatment and are at risk for other autoimmune diseases.
  • A 20-year-old female with T1DM presented with gastrointestinal issues and neurological complaints, eventually leading to a diagnosis of autoimmune gastritis after testing revealed low immunoglobulin A levels and elevated gastrin and parietal cell antibodies.
  • This case highlights the importance of monitoring and addressing potential autoimmune comorbidities in T1DM patients, as early recognition can improve treatment outcomes and overall health.
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  • Hepatocellular carcinoma (HCC) is a severe liver cancer often diagnosed at an advanced stage, limiting treatment options and necessitating effective systemic therapies.
  • Research indicates that growth hormone receptor (GHR) signaling contributes to HCC progression, and elevated growth hormone levels correlate with more aggressive disease and poorer outcomes in nearly half of HCC patients.
  • The study demonstrates that inhibiting GHR with pegvisomant shows promise as a new treatment for HCC, enhancing the effects of existing therapies like sorafenib and providing potential benefits for patients with drug-resistant cancer.
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Introduction: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancers. It is an aggressive neoplasm with dismal outcome because most of the patients present with an advanced-stage disease, which precludes curative surgical options. Therefore, these patients require systemic therapies that typically induce small improvements in overall survival.

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Gastric cancer is a common malignancy and remains one of the leading causes of cancer-related deaths, though its incidence is in decline in most developed countries. One of the major challenges of treating gastric cancer is tumor heterogeneity, which portends a high degree of prognostic variance and the necessity for different treatment modalities. Tumor heterogeneity is at least in part due to divergent differentiation of tumor cells to clones harboring different molecular alterations.

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