Key structural role of a conserved cis-proline revealed by the P285S variant of soybean serine hydroxymethyltransferase 8.

The enzyme serine hydroxymethyltransferase (SHMT) plays a key role in folate metabolism and is conserved in all kingdoms of life. SHMT is a pyridoxal 5'-phosphate (PLP) - dependent enzyme that catalyzes the conversion of L-serine and (6S)-tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. Crystal structures of multiple members of the SHMT family have shown that the enzyme has a single conserved cis proline, which is located near the active site.

Correlation of the Physician Assistant Education Association End of Rotation Examinations with the Physician Assistant National Certifying Exam.

Purpose: The purpose of this study was to determine whether student scores on the Physician Assistant Education Association (PAEA) End of Rotation™ subject examinations had a statistically significant relationship with subsequent performance on the Physician Assistant National Certifying Exam (PANCE). The raw scores achieved by students from 3 participating programs were correlated with scores on the PANCE.

Methods: Seven 120-question End of Rotation examinations, developed by the PAEA, were administered to students from 3 PA programs (n=72).