Publications by authors named "Jamie F Merves"
Article Synopsis
- Kohlmeier-Degos (K-D) disease is a rare vascular condition that can present in a mild cutaneous form or as severe systemic disease, particularly affecting the gastrointestinal tract, leading to high mortality rates due to bowel perforations.
- Symptoms of gastrointestinal K-D often precede perforation and include abdominal pain, weight loss, vomiting, and gastrointestinal bleeding, with the small intestine being the most common site of perforation.
- The most effective treatment involves a combination of eculizumab and treprostinil, and timely diagnostic laparoscopy is crucial for successful diagnosis and intervention.
Objective: The influence of eosinophilic oesophagitis (EoE)-associated inflammation upon oesophageal epithelial biology remains poorly understood. We investigated the functional role of autophagy in oesophageal epithelial cells (keratinocytes) exposed to the inflammatory EoE milieu.
Design: Functional consequences of genetic or pharmacological autophagy inhibition were assessed in endoscopic oesophageal biopsies, human oesophageal keratinocytes, single cell-derived ex vivo murine oesophageal organoids as well as a murine model recapitulating EoE-like inflammation and basal cell hyperplasia.