Role of vitamin B12 deficiency in ischemic stroke risk and outcome.

Currently, ischemic stroke is the most prevalent form of stroke compared to hemorrhagic and there is a high incidence in older adults. Nutrition is a modifiable risk factor for stroke. B-vitamins are part of a metabolic network that integrates nutritional signals with biosynthesis, redox homeostasis, and epigenetics.

Methylenetetrahydrofolate reductase deficiency alters cellular response after ischemic stroke in male mice.

Elevated homocysteine concentrations are a risk factor for stroke. A common genetic polymorphism in methylenetetrahydrofolate reductase ( 677 C→T) results in elevated levels of homocysteine. MTHFR plays a critical role in the synthesis of -adenosylmethionine (SAM), a global methyl donor.