TET1 overexpression attenuates paclitaxel-induced neuropathic pain through rescuing K1.1 expression in primary sensory neurons of male rats.

Aims: Paclitaxel-induced downregulation of two-pore domain K+ channel 1.1 (K1.1) caused by increasing DNA methylation within its gene promoter in the dorsal root ganglion (DRG) contributes to neuropathic pain.

Long noncoding RNA (lncRNA): a target in neuropathic pain.

Current treatments for neuropathic pain are limited in part due to the incomplete understanding of its underlying mechanisms. Recent evidence reveals the dysregulated expression of long non-coding RNAs (lncRNAs) in the damaged nerve, dorsal root ganglion (DRG), and spinal cord dorsal horn following peripheral nerve injury. However, the role of the majority of lncRNAs in neuropathic pain genesis is still elusive.