Publications by authors named "Jamie Barkin"
Objectives: This study aimed to provide patients insights on the management of exocrine pancreatic insufficiency (EPI) with pancreatic enzyme replacement therapy (PERT).
Materials And Methods: A survey of 75 members of Inspire's Pancreatitis or Pancreatic Cancer Support communities was conducted. Eligibility included having EPI secondary to chronic pancreatitis, pancreatic cancer, pancreatic surgery, or acute pancreatitis, and current/past PERT experience.
The prevalence of celiac disease (CD) is approximately 1% in the US. Studies have shown possible association between exocrine pancreatic insufficiency (EPI) and CD, with numerous hypothesized biological mechanisms including small bowel mucosal damage causing disruption of enteric-mediated hormonal secretion such as cholecystokinin and loss of enterokinase. The overall prevalence of EPI in CD remains unknown.
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- Patients with Clostridioides difficile infection (CDI) often have other health issues that need treatments that weaken their immune system.
- The study looked at many research papers to see how these treatments affected the health outcomes of CDI patients.
- It found that patients receiving immunosuppressive therapy had a higher risk of serious problems, like death or needing surgery, compared to those who didn't receive those treatments.
Article Synopsis
- * Researchers pooled data from two trials comparing pancrelipase to a placebo, measuring stool frequency, consistency, abdominal pain, and flatulence over time.
- * Results showed patients on pancrelipase had significantly reduced stool frequency and improved CFA, with these positive effects on symptoms persisting over a year of treatment.
Postcholecystectomy Biliary Clip Migration Causing Acute Pancreatitis.
ACG Case Rep J
September 2019
Article Synopsis
- Postcholecystectomy biliary clip migration, though rare, can lead to acute pancreatitis in patients who have undergone gallbladder removal surgery.
- A case study details a patient experiencing recurrent acute pancreatitis 15 and 19 months after laparoscopic cholecystectomy, with imaging indicating potential clip migration.
- To diagnose this condition, doctors can use plain radiographs to compare current and past imaging to check for changes in the number of biliary clips, which aids in determining the right treatment.
Patients with chronic pancreatitis (CP) may have a higher prevalence of osteoporosis than the general population thereby increasing the risk of bone fracture. The pathophysiology of bone disease in CP is multifactorial. Their risk factors for secondary osteoporosis include increasing age, low body mass index from sitophobia, maldigestion due to exocrine pancreatic insufficiency (EPI) with resulting low vitamin D, as well as smoking and alcohol abuse.
View Article and Find Full Text PDFObjectives: Small intestinal bacterial overgrowth (SIBO) is challenging to treat and diagnose and is associated with diagnosis of irritable bowel syndrome (IBS). Although no FDA-approved medications exist for treatment of SIBO, rifaximin has recently received approval to treat diarrhea-predominant IBS and patients with methane-positive SIBO breath tests. The aim of this study is to evaluate patient response to rifaximin for SIBO based on breath test results.
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- IgG4-related disease (IgG4-RD) is an autoimmune condition marked by the presence of IgG4 plasma cells in various organs, especially affecting the lungs.* -
- Lung issues related to IgG4-RD can manifest as inflammatory pseudotumors, interstitial pneumonitis, and organizing pneumonia, among others, and there’s no specific test to diagnose it.* -
- Treatment typically involves corticosteroids and possibly other rheumatoid drugs, but the long-term outlook for patients with IgG4-related lung disease (IgG4-RLD) is still unclear; the review also explores current diagnostic methods and areas for future research.*
Objectives: The aim of this study was to identify the prevalence of cannabis use among all patients admitted with acute pancreatitis (AP) in the United States and to investigate the impact of cannabis use on AP mortality, morbidity, and cost of care.
Methods: The National Inpatient Sample database from 2003 to 2013 was queried for all patients with AP and active exposure to cannabis. Outcomes included in-hospital mortality, length of stay, inflation adjusted charges, acute kidney injury, acute respiratory distress syndrome, and shock.
Article Synopsis
- Pancreatic cancer can lead to pancreatic exocrine insufficiency, requiring patients to use pancreatic enzyme replacement therapy (PERT) during meals for effective symptom relief.
- A study involving 262 pancreatic cancer patients found that taking PERT with meals significantly improved symptoms like indigestion and stool issues, as well as led to weight gain.
- Despite 89% of patients being prescribed PERT, only 65% used it correctly with meals, highlighting a need for better educational efforts for both patients and healthcare providers on PERT usage.
Objective: To investigate the prevalence and natural history of pancreatic pseudocysts (PCs) and parenchymal necrosis in autoimmune pancreatitis (AIP).
Method: A search using PubMed, Embase, Scopus, and Cochrane was performed. Search terms were AIP, PC, acute fluid collection, and pancreatic necrosis.
Background And Aim: Twenty-percentage of acute pancreatitis (AP) cases is labeled as idiopathic. Cannabis remains the most frequently used illicit drug in the world. The aim of this study was to identify the prevalence of cannabis use among all patients with a first episode of AP, particularly in those labeled as idiopathic etiology, and determine any effect on AP severity.
View Article and Find Full Text PDFPancreatic cancer is often detected in late stages, which contributes to its grim prognosis. Although the manifestations of pancreatic cancer most often include nonspecific gastrointestinal complaints, we report a case with the sole initial complaint of halitosis and subsequent diagnostic workup demonstrating a pancreatic mass with secondary pancreatocolonic fistulization. The etiologies of and the radiological findings pertaining to halitosis, the presenting symptoms and imaging studies relevant to the diagnosis of pancreatic cancer, and the imaging and clinical findings of pancreatic fistulization are discussed.
View Article and Find Full Text PDFObjectives: Cannabis is the most frequently consumed illicit drug in the world, with higher prevalence under the age of 35 years. Cannabis was first reported as a possible cause of acute pancreatitis (AP) in 2004. The aim of this systematic review is to examine cannabis use as an etiology of AP.
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