Peripheral HMGB1 is linked to O pathology of disease-associated astrocytes and amyloid.

Introduction: Ozone (O) is an air pollutant associated with Alzheimer's disease (AD) risk. The lung-brain axis is implicated in O-associated glial and amyloid pathobiology; however, the role of disease-associated astrocytes (DAAs) in this process remains unknown.

Methods: The O-induced astrocyte phenotype was characterized in 5xFAD mice by spatial transcriptomics and proteomics.

Sunlight activated film forming adhesive polymers.

Stimuli-sensitive biomaterials that are activated by light are in need of formulations that are stable under indoor lighting yet can be activated under direct sunlight. Carbene-based bioadhesives are a new generation of film-forming polymers that are stable under indoor lighting yet are rapidly activated with low-energy UVA light, but have never been evaluated under sunlight exposure. Previous investigations have evolved two flexible carbene-based platforms, where aryl-diazirine is grafted on to polyamidoamine dendrimers (PAMAM-NH; generation-5) or hydrophobic liquid polycaprolactone tetrol to yield G5-Dz and CaproGlu, respectively.