Performance evaluation of delefilcon a water gradient daily disposable contact lenses in first-time contact lens wearers.

Purpose: To evaluate the tolerability of and subject and investigator satisfaction with delefilcon A (DAILIES TOTAL1) daily disposable contact lenses in first-time contact lens wearers.

Methods: This European multicenter, open-label, single-arm, two-week trial enrolled first-time contact lens wearers and fitted them with delefilcon A contact lenses. Assessments were made at dispensing and at Weeks 1 and 2.

Systane® ultra lubricant eye drops for treatment of contact lens-related dryness.

Objectives: To assess the clinical performance of Systane Ultra lubricant eye drops in daily disposable soft contact lens wearers who experience contact lens-related dryness.

Methods: In this randomized, investigator-masked study, daily disposable lens wearers with symptoms of dryness were randomized to use Systane Ultra lubricant eye drops or to no treatment. The lubricant regimen was applied twice a day, 10 minutes before lens insertion and after lens removal, for the 2-week study period.

Rapid image evaluation system for corneal in vivo confocal microscopy.

Purpose: To develop rapid image processing techniques for the objective analysis of corneal in vivo confocal micrographs.

Methods: Perpendicular central corneal volume scans from healthy volunteers were obtained via laser in vivo confocal microscopy. The layer in each volume scan that contained the nerve plexus was detected by applying software operators to analyze image features on the basis of their size, shape, and contrast.

Comparative effect of lens care solutions on blink rate, ocular discomfort and visual performance.

Purpose: To help maintain clear vision and ocular surface health, eye blinks occur to distribute natural tears over the ocular surface, especially the corneal surface. Contact lens wearers may suffer from poor vision and dry eye symptoms due to difficulty in lens surface wetting and reduced tear production. Sustained viewing of a computer screen reduces eye blinks and exacerbates such difficulties.

Dendritic immune cell densities in the central cornea associated with soft contact lens types and lens care solution types: a pilot study.

Background: The purpose of this study was to assess whether differences in central corneal dendritic immune cell densities associated with combinations of soft contact lenses and lens care solutions could be detected by in vivo confocal microscopy.

Methods: Participants were adults naïve to contact lens wear (n = 10) or who wore soft contact lenses habitually on a daily-wear schedule (n = 38) or on a study-assigned schedule for 30 days with daily disposable silicone hydrogel lenses (n = 15). Central corneas were scanned using an in vivo confocal microscope.

Effects of fluorescein staining on laser in vivo confocal microscopy images of the cornea.

This study was designed to identify whether topical fluorescein, a common ophthalmic tool, affects laser in vivo confocal microscopy of the cornea, a tool with growing applications. Twenty-five eye care specialists were asked to identify presence or absence of fluorescein in 99 confocal micrographs of healthy corneas. Responses were statistically similar to guessing for the epithelium (48% ± 14% of respondents correct per image) and the subbasal nerve plexus (49% ± 11% correct), but results were less clear for the stroma.