Stability of ertapenem 100 mg/mL in polypropylene syringes stored at 25, 4, and -20 °C.

Purpose: The stability of ertapenem solution in syringes at room, refrigerator, and freezer temperatures was determined to establish options for extended storage.

Methods: Six replicate solutions of ertapenem (100 mg/mL) in 0.9% sodium chloride injection were prepared in 20-mL polypropylene syringes and stored at 25, 4, or -20 °C.

Humanized tissue pharmacodynamics of cefazolin against commonly isolated pathogens in skin and skin structure infections.

Objectives: The objective of this study was to assess the efficacy of humanized cefazolin tissue concentrations against methicillin-susceptible Staphylococcus aureus (MSSA) and Enterobacteriaceae in an in vitro pharmacodynamic model.

Methods: Nine clinical isolates [five MSSA (cefazolin MIC range 0.5-2.