Cancer incidence and mortality risks in a large US Barrett's oesophagus cohort.

Objective: Barrett's oesophagus (BE) increases the risk of oesophageal adenocarcinoma by 10-55 times that of the general population, but no community-based cancer-specific incidence and cause-specific mortality risk estimates exist for large cohorts in the USA.

Design: Within Kaiser Permanente Northern California (KPNC), we identified patients with BE diagnosed during 1995-2012. KPNC cancer registry and mortality files were used to estimate standardised incidence ratios (SIR), standardised mortality ratios (SMR) and excess absolute risks.

Proton Pump Inhibitor and Histamine-2 Receptor Antagonist Use and Iron Deficiency.

Background & Aims: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) suppress gastric acid production, which can inhibit iron absorption. However, few data exist regarding whether these medications increase the risk of clinical iron deficiency.

Methods: A community-based case-control study evaluated the association between acid-suppressing medication use and the subsequent risk of iron deficiency.

Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency.

Importance: Proton pump inhibitors (PPIs) and histamine 2 receptor antagonists (H2RAs) suppress the production of gastric acid and thus may lead to malabsorption of vitamin B12. However, few data exist regarding the associations between long-term exposure to these medications and vitamin B12 deficiency in large population-based studies.

Objective: To study the association between use of PPIs and H2RAs and vitamin B12 deficiency in a community-based setting in the United States.