Early Pulmonary Hypertension in Preterm Infants.

Pulmonary hypertension (PH) in preterm neonates has multifactorial pathogenesis with unique characteristics. Premature surfactant-deficient lungs are injured following exposure to positive pressure ventilation and high oxygen concentrations resulting in variable phenotypes of PH. The prevalence of early PH is variable and reported to be between 8% and 55% of extremely preterm infants.

Cell-shaped silicon-on-insulator microdosimeters: characterization and response to PuBe irradiations.

This work tested the feasibility of a silicon-on-insulator microdosimeter, which mimics the size and shape of specific cells within the human body, to determine dose equivalent from neutron irradiation. The microdosimeters were analyzed in terms of their basic diode characteristics, i.e.

Analytical model for ion stopping power and range in the therapeutic energy interval for beams of hydrogen and heavier ions.

Many different approaches exist to calculate stopping power and range of protons and heavy charged particles. These methods may be broadly categorized as physically complete theories (widely applicable and complex) or semi-empirical approaches (narrowly applicable and simple). However, little attention has been paid in the literature to approaches that are both widely applicable and simple.

Temporal Profile of Early Pulmonary Hypertension in Preterm Infants.

Objective The objective of this study was to study the temporal profile of pulmonary hypertension (PH) in preterm infants. Study Design Infants < 28 weeks were screened for early PH at 10 to 14 days of life. Infants with early PH (n = 10) and gestationally matched controls (n = 18) underwent serial echocardiography every 7 to 10 days until 36 weeks postmenstrual age.

Individuals Are Continents; or, Why It's Time to Retire the Island Approach to Addiction.

Individuals are not island isolates. This is an old insight that finds expression in indigenous worldviews, ancient philosophies, religious doctrine, and modern social theories. Even so, science remains encumbered by the false dichotomies and reductionism inherited from the capitalist revolution and reinforced by the fragmentation of modern life.

Pulmonary hypertension in preterm infants: prevalence and association with bronchopulmonary dysplasia.

Objective: To determine whether early pulmonary hypertension (PH) at 10-14 days of life in preterm infants is associated with bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age (PMA).

Study Design: This was a prospective observational cohort study of infants <28 weeks' gestation. Exclusion criteria were any major anomaly, genetic syndrome, or death before the initial echocardiogram.

Exercise-limiting symptoms in children.

Transient exercise-related symptoms are common in children and adolescents and only rarely reflect underlying cardiac and pulmonary disease processes. Most symptoms occurring during exercise reflect changes related to normal exercise physiology, changes in level of competition, and musculoskeletal and developmental factors. A rational approach to screening for potentially life-threatening cardiac conditions and exercise-induced bronchospasm is important to minimize the risk of misdiagnosis and to keep the young athlete active.

Intervertebral motion between flexion and extension in asymptomatic individuals.

Study Design: Measure and analyze variation in intervertebral motion in asymptomatic subjects.

Objectives: Gain further insight into intervertebral motion during flexion and extension in asymptomatic individuals, identify factors that contribute to variation in motion, and establish a quantitative database using a clinically practical imaging tool.

Summary Of Background Data: Several authors have reported on normal values for intervertebral motion during flexion and extension of the cervical spine.

Intracardiac yolk sac tumor and dysrhythmia as an etiology of pediatric syncope.

This report describes a new etiology of pediatric syncope. Epilepsy, brain anomalies, infection, electrolyte abnormalities, and trauma are commonly identified etiologies of seizures in the pediatric population. We report here a child with third-degree heart block and right ventricular outflow tract obstruction related to an intracardiac tumor presenting with syncope and seizure-like activity.

Metalloporphyrin probes for antimalarial drug action.

Metal-substituted protoporphyrin IXs (Co(III)PPIX (1), Cr(III)PPIX (2), Mn(III)PPIX (3), Cu(II)PPIX (4), Mg(II)PPIX (5), Zn(II)PPIX (6) and Sn(IV)PPIX (7)), phthalocyanine tetrasulfonates (PcS (8) and Ni(II)PcS (9)), and anionic and cationic porphyrins (meso-tetra(4-sulfonatophenyl)porphine (TPPS4, 10), meso-tetra(4-carboxyphenyl)porphine (TPPC4, 11), tetrakis(4-N-trimethylaminophenyl)porphine (TMAP, 12) and meso-tetra(N-methyl-4-pyridyl)porphine (TMPyP4, 13)) have been used as probes to compare two different assays for the inhibition of beta-hematin formation. The results demonstrate that the efficacy of these probes in either the beta-hematin inhibition assay (9, 7, 6, 5>4>11, 3>10, 8>2, 1; 12 and 13 did not inhibit.) or the bionucleating template assay (8>1>11>9, 2>4>3>7>10>5>6; 12 and 13 did not inhibit.

Hepatic dysfunction following the Fontan procedure.

Objectives: The Fontan procedure offers a palliation for the hemodynamic derangements associated with congenital heart lesions characterized by a single functional ventricle, but it causes a chronically elevated systemic venous pressure that may result in hepatic congestion. The objective of this study was to characterize hepatic function and its relationship to cardiac function in children who had undergone the Fontan procedure.

Methods: In a cross-sectional study of 11 children aged 38 months to 216 months (mean, 149 months), the authors evaluated indices of cardiac and hepatic function, including galactose clearance, Doppler hepatic ultrasonography, synthetic function, and markers of liver injury, at 9 months to 176 months (mean, 100 months) after children had undergone the Fontan procedure.