Publications by authors named "James Ziegenbein"
Article Synopsis
- Five New World mammarenaviruses (NWMs) can cause serious hemorrhagic fever, and they enter human cells using the transferrin receptor 1 (hTfR1).
- An antibody called ch128.1/IgG1 effectively blocks these viruses from infecting cells by targeting hTfR1 and preventing the viral GP1 protein from binding.
- In tests, ch128.1/IgG1 also protected genetically modified mice from lethal NWMs and showed promise as a therapeutic option without significantly disrupting normal iron uptake.
Pathogenic clade B New World mammarenaviruses (NWM) can cause Argentine, Venezuelan, Brazilian, and Bolivian hemorrhagic fevers. Sequence variability among NWM glycoproteins (GP) poses a challenge to the development of broadly neutralizing therapeutics against the entire clade of viruses. However, blockade of their shared binding site on the apical domain of human transferrin receptor 1 (hTfR1/CD71) presents an opportunity for the development of effective and broadly neutralizing therapeutics.
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