Publications by authors named "James W Lord"
Article Synopsis
- Oncogenic RAS mutations are prevalent in multiple myeloma (MM), a type of cancer affecting plasma cells, but understanding the signaling mechanisms of RAS in this disease has been challenging.
- Researchers used a proteogenomic approach to reveal that mutant RAS interacts with the amino acid transporter SLC3A2 and the protein MTOR on endolysosomes, which activates mTORC1 through amino acid pathways.
- The study shows that MM tumors with high mTORC1 activity and RAS mutations are more aggressive, and combining treatments to inhibit RAS-dependent mTORC1 along with MEK and ERK inhibitors offers a potential strategy for combating MM.
The painted urchin Lytechinus pictus is a sea urchin in the family Toxopneustidae and one of several sea urchin species that are routinely used as an experimental research organism. Recently, L. pictus has emerged as a tractable model system for establishing transgenic sea urchin lines due to its amenability to long term laboratory culture.
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