Publications by authors named "James Toner"

The countercurrent opinion given in this paper is that the optimal management of frozen embryo transfers (FET) is not a one-size-fits-all matter, but rather one that should be decided after considering all the various parameters and options. This choice should notably encompass patients' individual characteristics - including variable risks of obstetric complications - and weigh out the respective advantages of each FET option in each case. While there may be real advantages for natural-cycle FET in many cases, these need to be balanced against both practical and clinical issues.

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The workup of patients seeking assisted reproductive technology (ART) treatments has been modified by the tremendous improvements in ART efficacy accomplished recently. Moreover, the fact that ART is nowadays also offered to women who are not necessarily infertile-seeking genetic testing of their embryos-lead to important changes in how we investigate ART candidates. All the facets of these changes have been reviewed in the present introduction to this View-and-Review series on modern-day infertility workups.

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This study uses US national surveillance data to describe preimplantation genetic testing trends and outcomes between 2014 and 2018.

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Article Synopsis
  • The practice of in vitro fertilization (IVF) has evolved significantly since its inception in 1978, particularly in response to the high rates of twin and multiple births associated with early IVF methods.
  • From over 30% of IVF cycles resulting in twin or higher-order pregnancies in the mid-1990s, the rate decreased to less than 7% by 2019 due to advancements in technology and changes in medical guidelines.
  • These improvements included better embryo culturing and freezing techniques, genetic testing, and the standardization of single-embryo transfers, leading to an impressive 80% reduction in multifetal pregnancies while maintaining treatment success rates.
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Objective: To develop in vitro fertilization (IVF) prediction models to estimate the individualized chance of cumulative live birth at two time points: pretreatment (i.e., before starting the first complete cycle of IVF) and posttreatment (i.

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Objective: To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy.

Design: Review of English publications in PubMed and Embase to April 6, 2020.

Method(s): Articles were screened for reports including coronavirus, reproduction, pathophysiology, and pregnancy.

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Importance: In vitro fertilization (IVF) is associated with birth defects and imprinting disorders. Because these conditions are associated with an increased risk of childhood cancer, many of which originate in utero, descriptions of cancers among children conceived via IVF are imperative.

Objective: To compare the incidence of childhood cancers among children conceived in vitro with those conceived naturally.

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Objective: To assess the attitudes of Society for Assisted Reproductive Technology (SART) members regarding expanding insurance coverage for patients seeking assisted reproductive technologies (ART) and identify some of the factors that may influence such attitudes.

Design: An anonymous online 14-question survey of SART membership; 1,556 surveys were sent through the SART Research Portal from June to December 2017. Questions were incremental in scope, beginning with expanding insurance coverage for ART for vulnerable populations (e.

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Background: Children born from fresh in vitro fertilization (IVF) cycles are at greater risk of being born smaller and earlier, even when limited to singletons; those born from frozen cycles have an increased risk of large-for-gestational age (LGA) birthweight (z-score ≥1.28). This analysis sought to overcome limitations in other studies by using pairs of siblings, and accounting for prior cycle outcomes, maternal characteristics, and embryo state and stage.

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The Society for Assisted Reproductive Technology (SART) was established within a few years of assisted reproductive technology (ART) in the United States, and has not only reported on the evolution of infertility care, but also guided it toward improved success and safety. Moving beyond its initial role as a registry, SART has expanded its role to include quality assurance, data validation, practice and advertising guidelines, research, patient education and advocacy, and membership support. The success of ART in this country has greatly benefited from SART's role, as highlighted by a series of graphs.

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In 2013, the Minamata Convention on Mercury called for a global phase-down of amalgam use, with a view to reduce environmental mercury pollution. This will significantly impact UK dentistry, given the still extensive use of amalgam in U.K.

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Antimüllerian hormone is the most informative serum marker of ovarian reserve currently available and should be considered an important part of any contemporary reproductive medicine practice. It is both more convenient and informative than basal FSH and can be assessed at any point in the cycle. It is the most useful serum method of determining ovarian reserve, which guides pretreatment counseling, choice of infertility treatment, and avoidance of ovarian hyperstimulation.

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Objective: To determine if 3 months of preoperative gonadotropin-releasing hormone agonist (GnRH-a) treatment decreases postoperative uterine adhesions after open abdominal surgery for the removal of uterine fibroids.

Design: Prospective, randomized, clinical study.

Setting: A tertiary care medical center.

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Objective: To evaluate the relationship between early follicular phase levels of FSH and E(2) and outcomes of therapy with assisted reproductive technologies (ART).

Design: Retrospective cohort study.

Setting: ART centers in the United States.

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Markers of quantitative defects in egg production (low ovarian reserve) have often been used to exclude patients from treatment, even when egg quality is apt to be satisfactory. Women younger than 38 years of age with modest FSH elevations (10-15 or even 20 IU/L) have acceptable pregnancy rates despite their limited production of eggs ("quality matters more than quantity") and so should be given the opportunity to try IVF.

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