Publications by authors named "James T Nyirenda"
Article Synopsis
- Cryptosporidium is a gut pathogen that particularly affects people with weakened immune systems, such as those with HIV, and the CRYPTOFAZ trial in Malawi tested clofazimine's effectiveness for treating this infection.
- The study used various diagnostic methods, including qPCR and ELISA, to examine 586 individuals and monitor those who were part of the trial for pathogen shedding and other co-infections.
- The findings revealed that while qPCR was more sensitive for detecting Cryptosporidium, ELISA had more variable results; additionally, a new Cryptosporidium species was found, and enterotoxigenic E. coli was also linked to diarrhea in some participants.
Clin Vaccine Immunol
July 2017
Article Synopsis
- The study investigates how malaria affects children's immunity against nontyphoidal Salmonella (iNTS) infections, hypothesizing that malaria weakens both humoral and cellular immunity.
- Researchers measured specific immune responses in children with uncomplicated malaria, malaria-negative febrile illness, and nonfebrile conditions, finding reduced bactericidal activity and complement responses in those with malaria.
- The findings suggest that malaria compromises children's immune systems towards Typhimurium, increasing their susceptibility to iNTS infections, highlighting the need for further research on the underlying mechanisms.
