Array synthesis of novel lipodepsipeptide.

Synthetic array technology was utilized to rapidly synthesize and analyze a diverse set of reductive alkylation analogues of daptomycin. Analysis of the array suggested the use of polar functionality such as sulfonamides or amide or polar spaces such as piperazine would beneficially affect activity.

Synthesis and biological activity of N-Acylated ornithine analogues of daptomycin.

N-Acylated ornithine analogues of daptomycin were synthesized and tested for their antibacterial efficacy.