Convergence of autism proteins at the cilium.

Hundreds of high confidence autism genes have been identified, yet the relevant etiological mechanisms remain unclear. Gene ontology analyses have repeatedly identified enrichment of proteins with annotated functions in gene expression regulation and neuronal communication. However, proteins are often pleiotropic and these annotations are inherently incomplete.

Modulations of response activation contribute to block-wide control: Evidence from proportion congruency effects in the prime-probe task.

Distractor-related congruency effects are smaller in blocks of mostly incongruent (vs. mostly congruent) trials. It remains unclear, though, how control processes produce this proportion congruency effect (PCE).

Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility.

The comorbidity of autism spectrum disorders and severe gastrointestinal symptoms is well-established, yet the molecular underpinnings remain unknown. The identification of high-confidence large-effect autism risk genes offers the opportunity to identify convergent, underlying biology by studying these genes in the context of the gastrointestinal system. Here we show that the expression of these genes is enriched in human prenatal gut neurons as well as their migratory progenitors, suggesting that the development and/or function of these neurons may be disrupted by autism-associated pathogenic variants, leading to gastrointestinal dysfunction.

Proactive response preparation contributes to contingency learning: novel evidence from force-sensitive keyboards.

Contingency learning can involve learning that the identity of one stimulus in a sequence predicts the identity of the next stimulus. It remains unclear, however, whether such learning speeds responses to the next stimulus only by reducing the threshold for triggering the expected response after stimulus onset or also by preparing the expected response before stimulus onset. To distinguish between these competing accounts, we manipulated the probabilities with which each of two prime arrows (Left and Right) were followed by each of two probe arrows (Up and Down) in a prime-probe task while using force-sensitive keyboards to monitor sub-threshold finger force.

Dynamic measurement of gas flow using acoustic resonance tracking.

The National Institute of Standards and Technology measured gas flows exiting large, unthermostated, gas-filled, pressure vessels by tracking the time-dependent pressure P(t) and resonance frequency f(t) of an acoustic mode N of the gas remaining in each vessel. This is a proof-of-principle demonstration of a gas flow standard that uses P(t), f(t), and known values of the gas's speed of sound w(p,T) to determine a mode-weighted average temperature ⟨T⟩ of the gas remaining in a pressure vessel while the vessel acts as a calibrated source of gas flow. To track f(t) while flow work rapidly changed the gas's temperature, we sustained the gas's oscillations using positive feedback.

Is conflict adaptation adaptive? An introduction to conflict monitoring theory and the ecological problems it faces.

Attending to a single stimulus (or dimension of a stimulus) requires filtering out distracting stimuli to avoid producing an incorrect response. The conflict monitoring (or conflict adaptation) account proposes that experience of conflict results in a shift of attention away from distracting stimuli and/or towards the target stimulus. The proportion congruent and congruency sequence effects are two findings often used to argue in favour of the conflict monitoring account.

Measurement of the frequency dependence of four terminal-pair air capacitors with a vector network analyzer.

Four terminal-pair air capacitors are important transfer standards to calibrate LCR meters up to a frequency of 10 MHz. We report a simple and new method to obtain the frequency dependence of the four terminal-pair capacitance of these standards using a four-channel vector network analyzer (VNA). The frequency dependence of the capacitance of an air capacitor and its uncertainty can be obtained from a single set of measurements without changing connections between the standard and the VNA, as has been the case in previously published work.

Interlinguistic conflict: Word-word Stroop with first and second language colour words.

The congruency (or Stroop) effect is a standard observation of slower and less accurate colour identification to incongruent trials (e.g. "red" in green) relative to congruent trials (e.

Optimizing Recognition and Management of Patients at Risk for Infection-Related Decompensation Through Team-Based Decision Making.

Introduction: Pediatric sepsis is a leading cause of death among children. Electronic alert systems may improve early recognition but do not consistently result in timely interventions given the multitude of clinical presentations, lack of treatment consensus, standardized order sets, and inadequate interdisciplinary team-based communication. We conducted a quality improvement project to improve timely critical treatment of patients at risk for infection-related decompensation (IRD) through team-based communication and standardized treatment workflow.

Patterns of rates of mortality in the Clinical Practice Research Datalink.

The Clinical Practice Research Datalink (CPRD) is a widely used data resource, representative in demographic profile, with accurate death recordings but it is unclear if mortality rates within CPRD GOLD are similar to rates in the general population. Rates may additionally be affected by selection bias caused by the requirement that a cohort have a minimum lookback window, i.e.

Incidental learning in music reading: The music contingency learning task.

The present report investigated whether nonmusicians can incidentally learn musical skills needed for sight-reading. On each trial, participants identified a note name written inside of a note on the musical staff. In Experiment 1, each note was presented frequently with the congruent note name (e.

Stimulus and response conflict from a second language: Stroop interference in weakly-bilingual and recently-trained languages.

The aim of the present manuscript was to investigate the source of congruency effects in weak bilinguals (Experiment 1) and in early language learning (Experiment 2). In both studies, participants performed a bilingual version of a colour-word Stroop task. The standard finding is slower and less accurate responding when the word and colour are incongruent (e.

Pediatric croup with COVID-19.

We describe three previously healthy children, admitted from our emergency department (ED) to our free-standing children's hospital, as the first documented cases of croup as a manifestation of SARS-CoV-2 infection. All three cases (ages 11 months, 2 years, and 9 years old) presented with non-specific upper-respiratory-tract symptoms that developed into a barky cough with associated stridor at rest and respiratory distress. All were diagnosed with SARS-CoV-2 by polymerase chain reaction testing from nasopharyngeal samples that were negative for all other pathogens including the most common etiologies for croup.

Erasing the Homunculus as an Ongoing Mission: A Reply to the Commentaries.

In our recent article (Schmidt, Liefooghe, & De Houwer, 2020, this volume), we presented an adaptation of the Parallel Episodic Processing (PEP) model for simulating instruction following and task-switching behaviour. In this paper, we respond to five commentaries on our article: Monsell & McLaren (2020), Koch & Lavric (2020), Meiran (2020), Longman (2020), and Pfeuffer (2020). The commentaries discuss potential future modelling goals, deeper reflections on cognitive control, and some potential challenges for our theoretical perspective and associated model.

An Episodic Model of Task Switching Effects: Erasing the Homunculus from Memory.

The Parallel Episodic Processing (PEP) model is a neural network for simulating human performance in speeded response time tasks. It learns with an exemplar-based memory store and it is capable of modelling findings from various subdomains of cognition. In this paper, we show how the PEP model can be designed to follow instructions (e.

The Law of Recency: An Episodic Stimulus-Response Retrieval Account of Habit Acquisition.

A habit is a regularity in automatic responding to a specific situation. Classical learning psychology explains the emergence of habits by an extended learning history during which the response becomes associated to the situation (learning of stimulus-response associations) as a function of practice ("law of exercise") and/or reinforcement ("law of effect"). In this paper, we propose the "law of recency" as another route to habit acquisition that draws on episodic memory models of automatic response regulation.

Contingency learning as binding? Testing an exemplar view of the colour-word contingency learning effect.

The learning of contingent regularities between events is fundamental for interacting with our world. We are also heavily influenced by recent experiences, as frequently studied in the stimulus-response binding literature. According to one view ("unitary view"), the learning of regularities across many events and the influence of recent events on current performance can coherently be explained with one high-learning rate memory mechanism.

The Use of Coffee to Decrease the Incidence of Postoperative Ileus: A Systematic Review and Meta-Analysis.

Purpose: To investigate the efficacy of providing coffee to elective abdominal surgery patients, immediately postoperatively, to lessen postoperative ileus.

Design: A systematic review with meta-analysis of six randomized controlled trials published since 2012.

Methods: Methodological quality was evaluated using the Cochrane guidelines.

Measuring Adaptive Control in Conflict Tasks.

The past two decades have witnessed an explosion of interest in the cognitive and neural mechanisms of adaptive control processes that operate in selective attention tasks. This has spawned not only a large empirical literature and several theories but also the recurring identification of potential confounds and corresponding adjustments in task design to create confound-minimized metrics of adaptive control. The resulting complexity of this literature can be difficult to navigate for new researchers entering the field, leading to suboptimal study designs.

Stroop-like effects of derived stimulus-stimulus relations.

Automaticity can be established by consistently reinforcing contingencies during practice. During reinforcement learning, however, new relations can also be derived, which were never directly reinforced. For instance, reinforcing the overlapping contingencies A → B and A → C, can lead to a new relation B-C, which was never directly reinforced.

Propofol Versus Dexmedetomidine for Procedural Sedation in a Pediatric Population.

Objectives: Frequently, infants and children require sedation to facilitate noninvasive procedures and imaging studies. Propofol and dexmedetomidine are used to achieve deep procedural sedation in children. The objective of this study was to compare the clinical safety and efficacy of propofol versus dexmedetomidine in pediatric patients undergoing sedation in a pediatric sedation unit.

Evidence against conflict monitoring and adaptation: An updated review.

One of the most influential ideas in recent decades in the cognitive psychology literature is conflict monitoring theory. According to this account, each time we experience a conflict (e.g.

High salt diet impairs cerebral blood flow regulation via salt-induced angiotensin II suppression.

Objectives: This study sought to determine whether salt-induced ANG II suppression contributes to impaired CBF autoregulation.

Methods: Cerebral autoregulation was evaluated with LDF during graded reductions of blood pressure. Autoregulatory responses in rats fed HS (4% NaCl) diet vs LS (0.

Context-specific proportion congruent effects: Compound-cue contingency learning in disguise.

Conflict between task-relevant and task-irrelevant stimulus information leads to impairment in response speed and accuracy. For instance, in the colour-word Stroop paradigm, participants respond slower and less accurately to the print colour of incongruent colour words (e.g.