Arm weight effects on dynamic walking stability in individuals with hemiparetic stroke.

This study examined the effects of arm weights on dynamic stability during overground walking in individuals with hemiparetic stroke. Arm weights have been shown to improve mobility in stroke survivors, potentially at the cost of decreased dynamic stability and increased fall risk. Data from nine stroke survivors (8 males, 1 female; age: 58.

Handling Partially Observed Trial Data After Treatment Withdrawal: Introducing Retrieved Dropout Reference-Base Centred Multiple Imputation.

The ICH E9(R1) Addendum (International Council for Harmonization 2019) suggests treatment-policy as one of several strategies for addressing intercurrent events such as treatment withdrawal when defining an estimand. This strategy requires the monitoring of patients and collection of primary outcome data following termination of randomised treatment. However, when patients withdraw from a study early before completion this creates true missing data complicating the analysis.

Comments on 'standard and reference-based conditional mean imputation': Regulators and trial statisticians be aware!

Accurate frequentist performance of a method is desirable in confirmatory clinical trials, but is not sufficient on its own to justify the use of a missing data method. Reference-based conditional mean imputation, with variance estimation justified solely by its frequentist performance, has the surprising and undesirable property that the estimated variance becomes smaller the greater the number of missing observations; as explained under jump-to-reference it effectively forces the true treatment effect to be exactly zero for patients with missing data.

The Effect of Exercise-Induced Central Fatigue on Cervical Spine Joint Position Error, Strength, and Endurance.

Background: Fatigue is common in sports, impairing performance and increasing injury risk, yet little is known regarding fatigue and concussion. Impaired neck neuromuscular function may contribute to concussion at baseline, where central fatigue may further impair neck function resulting in increased concussion risk. These effects may be magnified in athletes with a history of concussion.

Adaptation in motor strategies for postural control associated with sensory reweighting.

The purpose of this study was to identify and differentiate the motor strategies associated with sensory reweighting adapted during specific sensory integration tasks by healthy young adults. Thirty-six subjects (age range: 21-33 years) performed standing computerized dynamic posturography balance tasks across progressively increasing amplitudes of visual (VIS), somatosensory (SOM) and both (VIS+SOM) systems perturbation conditions. Adaptation in the motor strategy was measured as changes in electromyographic (EMG) activities and joint angles.

Exploration of arm weight effects on hemiparetic stroke participants' gait performance.

Background: This study explores the potential benefits of an arm weight intervention for improving gait performance in stroke survivors. Consistent with an interlimb neural coupling mechanism, the investigators hypothesized that arm weight would improve gait performance.

Methods: Nine stroke and nine healthy participants (1 female; age: 58.

Evaluation of Criteria2Query: Towards Augmented Intelligence for Cohort Identification.

Electronic healthcare records data promises to improve the efficiency of patient eligibility screening, which is an important factor in the success of clinical trials and observational studies. To bridge the sociotechnical gap in cohort identification by end-users, who are clinicians or researchers unfamiliar with underlying EHR databases, we previously developed a natural language query interface named Criteria2Query (C2Q) that automatically transforms free-text eligibility criteria to executable database queries. In this study, we present a comprehensive evaluation of C2Q to generate more actionable insights to inform the design and evaluation of future natural language user interfaces for clinical databases, towards the realization of Augmented Intelligence (AI) for clinical cohort definition via e-screening.

100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care - Preliminary Report.

Background: The U.K. 100,000 Genomes Project is in the process of investigating the role of genome sequencing in patients with undiagnosed rare diseases after usual care and the alignment of this research with health care implementation in the U.

Immediate Improvements in Patellofemoral Pain Are Associated With Sagittal Plane Movement Training to Improve Use of Gluteus Maximus Muscle During Single Limb Landing.

Objective: The authors sought to examine the immediate effects of movement training aimed at improving use of gluteus maximus (GMAX) in the sagittal plane on hip internal rotation and self-reported patellofemoral pain (PFP) during single-limb landing.

Methods: Seventeen females with PFP participated. Lower extremity kinematics and kinetics, GMAX activation, and self-reported PFP were obtained before and after a single-session movement training program aimed at increasing the use of GMAX.

Gross Motor Skills and Gait Performance in Two- and Three-year-old Children With Developmental Delay Participating in Hippotherapy.

This study examined the effects of 15 sessions of hippotherapy (HPOT) on gross motor skills in children (aged 2-3 years) with gross motor developmental delay (DD) (n = 11) in comparison with age-based controls without DD (n = 6). Gross motor skills in both groups were assessed with the Battelle Developmental Inventory 2nd Edition, and gait parameters were measured using a computerized gait analysis system prestudy and poststudy. The DD group took part in 15 sessions of HPOT, and the control (CON) group did not participate in any equine activities.

Upper limb neurodynamic testing with radial and ulnar nerve biases: An analysis of cervical spinal nerve mechanics.

Background: Clinical research supports a combination of upper limb neurodynamic testing (ULNT) strategies to rule out upper limb and cervical neurogenic pathology; however, knowledge of the biomechanical response of spinal nerves during ULNT is lacking for radial and ulnar nerve biases.

Objective: To assess whether radial and ulnar nerve biased strategies of ULNT elicit significant displacement and strain of cervical spinal nerves.

Study Design: Cross-sectional.

The relationship between measures of foot mobility and subtalar joint stiffness using vibration energy with color Doppler imaging-A clinical proof-of-concept validation study.

Introduction: Subtalar joint (STJ) dysfunction can contribute to movement disturbances. Vibration energy with color Doppler imaging (VECDI) may be useful for detecting STJ stiffness changes.

Objectives: (1) Support proof-of-concept that VECDI could detect STJ stiffness differences; (2) Establish STJ stiffness range in asymptomatic volunteers; (3) Examine relationships between STJ stiffness and foot mobility; and (4) Assess VECDI precision and reliability for examining STJ stiffness.

THE EFFECTS OF POSTERIOR TIBIAL MOBILIZATION ON MENISCAL MOVEMENT: AN IN-SITU INVESTIGATION.

Background: Anterior knee pain during knee extension may be related to a meniscal movement restriction and increased meniscal load during function. One method of treatment involves the use of manual posterior mobilization of the tibia to specifically target the meniscotibial interface of the knee joint.

Purpose: The purpose of this study was to measure motion at a cadaveric medial meniscus anterior horn during a posterior tibial mobilization.

Weighted vest effects on impact forces and joint work during vertical jump landings in men and women.

Weighted vest (WV) use during vertical jump landings (VJL) does not appear to alter peak vertical ground reaction forces (GRF) or peak joint torques. However, WV effects on joint work and sex differences during VJL are not well understood. This study assessed WV effects on vertical GRF and sagittal joint work during VJL in men and women.

Volitional Preemptive Abdominal Contraction and Upper Extremity Muscle Latencies During D1 Flexion and Scaption Shoulder Exercises.

Context: The abdominal-bracing maneuver, a volitional preemptive abdominal contraction (VPAC) strategy, is commonly used during resisted shoulder exercises. How VPAC affects shoulder-muscle function during resisted shoulder exercise is unknown.

Objective: To identify the effects of VPAC on selected parascapular and glenohumeral muscles during specific shoulder exercises with or without resistance.

Treatment policy estimands for recurrent event data using data collected after cessation of randomised treatment.

In the past, many clinical trials have withdrawn subjects from the study when they prematurely stopped their randomised treatment and have therefore only collected 'on-treatment' data. Thus, analyses addressing a treatment policy estimand have been restricted to imputing missing data under assumptions drawn from these data only. Many confirmatory trials are now continuing to collect data from subjects in a study even after they have prematurely discontinued study treatment as this event is irrelevant for the purposes of a treatment policy estimand.

Elevated Levels of Alpha Cells Emanating from the Pancreatic Ducts of a Patient with a Low BMI and Chronic Pancreatitis.

Chronic pancreatitis (CP) is an inflammatory disease that causes progressive damage to the pancreatic parenchyma with irreversible morphological changes and fibrotic replacement of the gland. The risk factors associated with developing CP have been described as toxic (e.g.

Effects of arm weight on gait performance in healthy subjects.

Previous studies have investigated how additional arm weights affect gait. Although light weights (0.45 kg) seemed to elicit performance improvements in Parkinsonian patients, it was not studied how light weights affect gait parameters in healthy individuals.

Estimating the variance for heterogeneity in arm-based network meta-analysis.

Network meta-analysis can be implemented by using arm-based or contrast-based models. Here we focus on arm-based models and fit them using generalized linear mixed model procedures. Full maximum likelihood (ML) estimation leads to biased trial-by-treatment interaction variance estimates for heterogeneity.

Kinetic and Electromyographic Subphase Characteristics With Relation to Countermovement Vertical Jump Performance.

This study sought to identify kinetic and electromyographic subphase characteristics distinguishing good from poor jumpers during countermovement vertical jumps (CMVJs), as defined by the reactive strength index (RSI, CMVJ displacement divided by jump time; cutoff = 0.46 m·s). A total of 15 men (1.

Changes in patellofemoral pain resulting from repetitive impact landings are associated with the magnitude and rate of patellofemoral joint loading.

Background: Although a relationship between elevated patellofemoral forces and pain has been proposed, it is unknown which joint loading variable (magnitude, rate) is best associated with pain changes. The purpose of this study was to examine associations among patellofemoral joint loading variables and changes in patellofemoral pain across repeated single limb landings.

Methods: Thirty-one females (age: 23.

Performance Differences Among Skilled Soccer Players of Different Playing Positions During Vertical Jumping and Landing.

Harry, JR, Barker, LA, James, CR, and Dufek, JS. Performance differences among skilled soccer players of different playing positions during vertical jumping and landing. J Strength Cond Res 32(2): 304-312, 2018-Both jumping and landing performance of skilled soccer players is diminished when task demands are increased.

Prediction of calcaneal bone competence from biomechanical accommodation variables measured during weighted walking.

Carrying weight while walking is a common activity associated with increased musculoskeletal loading, but not all individuals accommodate to the weight in the same way. Different accommodation strategies could lead to different skeletal forces, stimuli for bone adaptation and ultimately bone competence. The purpose of the study was to explore the relationships between calcaneal bone competence and biomechanical accommodation variables measured during weighted walking.