Publications by authors named "James Ro"
The structure and function of the mammalian gut vary by region, yet why inflammatory diseases manifest in specific regions and not others remains unclear. We use a TNF-overexpressing Crohn's disease (CD) model (Tnf ), which typically presents in the terminal ileum (TI), to investigate how environmental factors interact with the host's immune susceptibility to drive region-specific disease. We identified , an intracellular bacterium and murine counterpart to the human sexually transmitted , as necessary and sufficient to trigger disease manifestation in the ascending colon (AC), another common site of human CD.
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- The tumor microenvironment in colorectal tumors consists of diverse cell types, and understanding their interactions is crucial for grasping tumor complexity.
- This study utilized single-cell RNA sequencing and other advanced imaging techniques to compare microenvironments in two mouse models of colorectal tumors — one sporadic and one driven by inflammation.
- Results showed distinct differences between the tumor types, particularly in the abundance of cancer-associated fibroblasts and the presence of unique squamous cells, highlighting their roles in tumor progression, especially in inflammation-driven cancer models.
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps.
Cell
December 2021
Article Synopsis
- Colorectal cancers develop from polyps, and this study creates a detailed single-cell atlas of conventional adenomas and serrated polyps to understand their origins and characteristics.
- The research reveals that adenomas stem from the growth of stem cells driven by WNT signaling, while serrated polyps emerge from differentiated cells undergoing gastric metaplasia, which leads to a damaged immune environment.
- The findings highlight how changes in tumor cell differentiation affect immune responses and contribute to cancer progression, offering valuable insights for more targeted monitoring and prevention strategies for colorectal cancer.
The spatial structure of dye-doped polymer-nanoparticle gain media, reported to generate spatially homogeneous single-transverse-mode laser beams, has been examined by electron microscopy in the nanometer scale. It is found that the distribution of the silica nanoparticles in the laser dye-doped polymer is fairly uniform. There is some aggregation of silica particles into loose nanoclusters.
View Article and Find Full Text PDFTunable laser action in the visible spectrum has been established for what is believed to be the first time by use of dye-doped, polymer-silica nanoparticle gain media. The silica nanoparticles, ranging from 9 to 12 nm in diameter, appear to be uniformly dispersed in the poly(methyl methacrylate) matrix because the optical homogeneity of the gain medium is maintained. With Rhodamine 6G dye and 30% weight-by-weight silica nanoparticles, laser action was established in the 567-603-nm range.
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