The accuracy of Eclipse AXB and AAA dose algorithms with dental amalgam.

High-density materials used for dental restorations are poorly defined in CT imaging due to scanner limitations. Studies have established that Eclipse offers poor agreement with delivered dose in situations involving high-density material. Defining the accuracy of dose algorithms in situations involving high-density overrides would improve clinical outcomes both for target coverage and OAR sparing.

Intrafraction Motion and Margin Assessment for Ethos Online Adaptive Radiotherapy Treatments of the Prostate and Seminal Vesicles.

Purpose: Online adaptive radiation therapy (OART) uses daily imaging to identify changes in the patient's anatomy and generate a new treatment plan adapted to these changes for each fraction. The aim of this study was to determine the intrafraction motion and planning target volume (PTV) margins required for an OART workflow on the Varian Ethos system.

Methods And Materials: Sixty-five fractions from 13 previously treated OART patients were analyzed for this retrospective study.

Clinical assessment of a novel machine-learning automated contouring tool for radiotherapy planning.

Contouring has become an increasingly important aspect of radiotherapy due to inverse planning. Several studies have suggested that the clinical implementation of automated contouring tools can reduce inter-observer variation while increasing contouring efficiency, thereby improving the quality of radiotherapy treatment and reducing the time between simulation and treatment. In this study, a novel, commercial automated contouring tool based on machine learning, the AI-Rad Companion Organs RT™ (AI-Rad) software (Version VA31) (Siemens Healthineers, Munich, Germany), was assessed against both manually delineated contours and another commercially available automated contouring software, Varian Smart Segmentation™ (SS) (Version 16.

Individualized breathing trace quality assurance for lung radiotherapy patients undergoing 4DCT simulation.

4DCT simulation is a popular solution for radiotherapy simulation of lung cancer patients as it allows the clinician to gain an appreciation for target motion during the patient breathing cycle. Resultant binning of images and production of the 4DCT dataset relies heavily on the recorded breathing trace; but quality assurance is not routinely performed on these and there lacks any substantial recommendations thereof. An application was created for Windows in C# that was able to analyze the VXP breathing trace files from Varian RPM/RGSC and quantify various metrics associated with the patient breathing cycle.

Varian ethos online adaptive radiotherapy for prostate cancer: Early results of contouring accuracy, treatment plan quality, and treatment time.

The Varian Ethos system allows for online adaptive treatments through the utilization of artificial intelligence (AI) and deformable image registration which automates large parts of the anatomical contouring and plan optimization process. In this study, treatments of intact prostate and prostate bed, with and without nodes, were simulated for 182 online adaptive fractions, and then a further 184 clinical fractions were delivered on the Ethos system. Frequency and magnitude of contour edits were recorded, as well as a range of plan quality metrics.

Investigation of elastomeric materials for bolus using stereolithography printing technology in radiotherapy.

Purpose: An investigation was conducted of an elastomeric material, VisiJet M2 (3D systems, USA) for use as 3D bolus within high energy photon beams for radiotherapy. Personalized conformal bolus material on complex structures like the nose can be challenging. This material was evaluated for its clinical feasibility due to its pliability and comfort compared to alternatives.

A review of stereotactic body radiotherapy for the spine.

Radiation therapy of the spine, as recourse for spinal tumours, is an effective method of achieving pain reduction and local control. Hypofractionated techniques like stereotactic body radiation therapy and especially stereotactic radiosurgery are quickly becoming more popular as studies are published demonstrating their superior outcomes. This review concerns aspects of spinal radiotherapy of interest to the clinical medical physicist, with a focus on stereotactic techniques.

An assessment of the ExacTrac intrafraction imaging capabilities for flattening filter free prostate stereotactic body radiotherapy.

The uncertainties associated with image matching using the ExacTrac® system (BrainLab, Munich, Germany) have been the subject of investigation in the literature for extra-cranial sites. However, the uncertainties involved in the use of ExacTrac in the presence of higher scatter conditions like that for intrafraction imaging of prostate stereotactic radiotherapy utilising unflattened beams is yet to be determined. A prostate phantom was created with 3 implanted gold fiducial markers.

Linear accelerator bunker shielding for stereotactic radiotherapy.

Shielding protocols such as NCRP 151, IAEA SRS 47 and IPEM 47 are commonly used for the design of radiotherapy facilities. Some work has been accomplished in updating the basic formula with the advent of IMRT but little consideration has been made for unflattened beams and stereotactic techniques apart from for facilities housing devices like the CyberKnife. The inevitable scenario of a stereotactic-only linear accelerator was considered in this study.

Conservatism in linear accelerator bunker shielding.

Conservatism in the shielding of linear accelerator bunkers is engrained in the methodology of international protocols and guidelines. However, the degree to which this cautious and prudent approach is necessary should be judged against the International Committee of Radiation Protection's principles of exposure justification and optimisation. Radiation survey data from 75 concrete barriers was aggregated and compared to exposure predictions from three popular protocols in order to assess any conservatism in factors used to calculate scatter, leakage and beam penetration.

Distributive quality assurance and delivery of stereotactic ablative radiotherapy treatments amongst beam matched linear accelerators: A feasibility study.

Purpose: Beam matching occurs on all linacs to some degree and when two are more are matched to each other, patients are able to be transferred between machines. Quality assurance of plans can also be performed "distributively" on any of the matched linacs. The degree to which machines are matched and how this translates to like delivery of plans has been the focus of a number of studies.

Effect of arc length on skin dose from hypofractionated volumetric modulated arc radiotherapy treatments of the lung and spine.

Due to large doses per fraction, stereotactic ablative radiotherapy of lung or spine can lead to skin tissue toxicity, the amount of which depends on a variety of factors such as target location, beam geometry, and immobilization. The effect of arc length on spreading out entrance and exit doses and the corresponding predictions of skin reactions has not yet been studied for stereotactic body radiotherapy volumetric modulated arc therapy (VMAT) treatments. 58 clinically relevant VMAT stereotactic body radiotherapy spine and lung plans were created for an anthropomorphic phantom utilizing a range of target locations, beam geometries and arc lengths.

Improving accuracy for stereotactic body radiotherapy treatments of spinal metastases.

Purpose: Use of SBRT techniques is now a relatively common recourse for spinal metastases due to good local control rates and durable pain control. However, the technique has not yet reached maturity for gantry-based systems, so work is still required in finding planning approaches that produce optimum conformity as well as delivery for the slew of treatment planning systems and treatment machines.

Methods: A set of 32 SBRT spine treatment plans based on four vertebral sites, varying in modality and number of control points, were created in Pinnacle.

A simple method to account for skin dose enhancement during treatment planning of VMAT treatments of patients in contact with immobilization equipment.

Purpose: The ability to accurately predict skin doses and thereby design radiotherapy treatments that balance the likelihood of skin reactions against other treatment objectives is especially important when hypofractionated prescription regimes are used. However, calculations of skin dose provided by many commercial radiotherapy treatment planning systems are known to be inaccurate, especially if the presence of immobilization equipment is not accurately taken into account. This study proposes a simple method by which the accuracy of skin dose calculations can be substantially improved, to allow informed evaluation of volumetric modulated arc therapy (VMAT) treatment plans.

Dose uncertainties associated with a set density override of unknown hip prosthetic composition.

The dosimetric uncertainties associated with radiotherapy through hip prostheses while overriding the implant to a set density within the TPS has not yet been reported. In this study, the uncertainty in dose within a PTV resulting from this planning choice was investigated. A set of metallic hip prosthetics (stainless steel, titanium, and two different Co-Cr-Mo alloys) were CT scanned in a water bath.

Post-upgrade testing on a radiotherapy oncology information system with an embedded record and verify system following the IAEA Human Health Report No. 7 recommendations.

Record and verify (R&V) systems have proven that their application in radiotherapy clinics leads to a significant reduction in mis-treatments of patients. The purpose of this technical note is to share our experience of acceptance testing, commissioning and setting up a quality assurance programme for the MOSAIQ® oncology information system and R&V system after upgrading from software version 2.41 to 2.

Comparison of effective I-131 half-life between thyroid hormone withdrawal and recombinant human thyroid-stimulating hormone for thyroid cancer: a retrospective study.

Introduction: Preparation for postoperative radioiodine ablation for differentiated thyroid carcinoma is performed by either thyroid hormone withdrawal or recombinant human thyroid-stimulating hormone (rhTSH) administration. There is little information on the impact of the method of preparation with respect to whole-body effective I-131 half-life and its potential clinical implications in the Australian setting.

Methods: A retrospective study was performed on patients admitted for adjuvant radioiodine ablation for non-metastatic differentiated thyroid carcinoma at the Royal Adelaide Hospital over a 4½-year period from 2009.