Publications by authors named "James Requa"

Background: Skin cancers are the most common malignancies diagnosed worldwide. While the early detection and treatment of pre-cancerous and cancerous skin lesions can dramatically improve outcomes, factors such as a global shortage of pathologists, increased workloads, and high rates of diagnostic discordance underscore the need for techniques that improve pathology workflows. Although AI models are now being used to classify lesions from whole slide images (WSIs), diagnostic performance rarely surpasses that of expert pathologists.

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Background And Aims: A reliable assessment of bowel preparation is important to ensure high-quality colonoscopy. Current bowel preparation scoring systems are limited by interobserver variability. This study aimed to demonstrate objective assessment of bowel preparation adequacy using an artificial intelligence (AI)/convolutional neural network (CNN) algorithm developed from colonoscopy videos.

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Article Synopsis
  • Endoscopic disease activity scoring for ulcerative colitis (UC) is essential but rarely performed, leading to calls for automation through machine learning to improve clinical practice and research.
  • Researchers collected 795 endoscopy videos from a trial involving 249 patients to train a recurrent neural network (RNN) that could predict endoscopic Mayo scores (eMS) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) from these videos.
  • The RNN model showed excellent agreement with human expert scores, achieving a quadratic weighted kappa (QWK) of 0.844 for eMS and 0.855 for UCEIS, indicating its potential for effectively assessing UC severity in clinical settings.
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Background And Aims: The visual detection of early esophageal neoplasia (high-grade dysplasia and T1 cancer) in Barrett's esophagus (BE) with white-light and virtual chromoendoscopy still remains challenging. The aim of this study was to assess whether a convolutional neural artificial intelligence network can aid in the recognition of early esophageal neoplasia in BE.

Methods: Nine hundred sixteen images from 65 patients of histology-proven early esophageal neoplasia in BE containing high-grade dysplasia or T1 cancer were collected.

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Objectives: Reliable in situ diagnosis of diminutive (≤5 mm) colorectal polyps could allow for "resect and discard" and "diagnose and leave" strategies, resulting in $1 billion cost savings per year in the United States alone. Current methodologies have failed to consistently meet the Preservation and Incorporation of Valuable endoscopic Innovations (PIVIs) initiative thresholds. Convolutional neural networks (CNNs) have the potential to predict polyp pathology and achieve PIVI thresholds in real time.

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