Publications by authors named "James R W Glanville"
Article Synopsis
- Dendritic cells (DC) are essential immune cells that connect the body's innate and adaptive immune responses, with two main types: plasmacytoid DC (pDC) and conventional DC (cDC).
- Research using in vivo deuterium-glucose labeling revealed that a specific subset of cDC known as AXL+ Siglec6+ DC (ASDC) circulates in the bloodstream for about 2.16 days, while other cDC types have slightly shorter lifespans.
- The study also showed that ASDC are quickly recruited to inflamed areas, highlighting their role in managing immune responses during inflammation and suggesting new insights into the behavior of different DC subsets.
Article Synopsis
- Recent research indicates that resolving inflammation is more complex than previously thought, involving a prolonged phase of immune activity rather than a simple return to balance.
- Following initial lung inflammation caused by Streptococcus pneumoniae, specific immune cells like memory T cells and various macrophages re-enter the tissue, showing changes in their genetic activity that facilitate further immune responses.
- Blocking prostaglandin E2 (PGE2) signaling, particularly through the EP4 receptor, leads to reduced T cell populations and increased tissue damage, highlighting the importance of PGE2 in nurturing T cell development and preventing injury during the immune response recovery phase.
ATB-346 is a hydrogen sulfide-releasing non-steroidal anti-inflammatory drug (H S-NSAID) derived from naproxen, which in preclinical studies has been shown to have markedly reduced gastrointestinal adverse effects. However, its anti-inflammatory properties in humans compared to naproxen are yet to be confirmed. To test this, we used a dermal model of acute inflammation in healthy, human volunteers, triggered by ultraviolet-killed Escherichia coli.
View Article and Find Full Text PDFA 53-year-old woman attended for a routine outpatient appointment for follow-up of antineutrophil cytoplasmic antibody-positive vasculitis. Her disease had relapsed despite appropriate medical management with mycophenolate mofetil (MMF), as evidenced by rising acute phase response and antimyeloperoxidase titre with ongoing symptoms. On further questioning, she had been taking oral charcoal as part of a detoxification diet, which we postulate was causing significantly impaired MMF absorption.
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