Effects of mid-respiratory chain inhibition on mitochondrial function and .

Relating the mitochondrial effects of drug candidates to likely outcomes remains challenging. Better understanding of this relationship, alongside improved methods to assess mitochondrial dysfunction , would both guide safer drug candidate selection and better support discovery programmes targeting mitochondria for pharmacological intervention. The aim of this study was to profile the effects of a compound with suspected complex III electron transport chain (ETC) inhibitory activity (GSK932121A) at doses associated with clinical signs, and relate findings back to data with the same compound.