Waxy fingers and skin tethering.

The patient sought care for a burn he hadn't felt when he'd held a hot cup of coffee. His history, and the appearance of his hands, suggested a systemic disease at work.

Double Distal Intraneural Fascicular Nerve Transfers for Lower Brachial Plexus Injuries.

Purpose: To evaluate outcomes following transfer of the supinator motor branch of the radial nerve (SMB) to the posterior interosseous nerve (PIN) and the pronator teres motor branch of median (PTMB) to the anterior interosseous nerve (AIN) in patients with lower brachial plexus injuries.

Methods: Since December 2010, 4 patients have undergone combined transfer of the SMB to PIN and PTMB to AIN for lower brachial plexus palsies. The study was prospectively designed, and the patients were followed for 4 years to monitor their functional improvement.

Involvement of TRP channels in the CO₂ chemosensitivity of locus coeruleus neurons.

Catecholaminergic neurons in the locus coeruleus (LC) play a role in the ventilatory response to hypercapnia. Here, we show evidence for the involvement of transient receptor potential (TRP) channels. We found that the input resistance was reduced during an exposure to 8% CO(2) in ~35% LC neurons in mouse brain slices, accompanied by depolarization and higher firing activity.