Publications by authors named "James Paul"
Competent endoscopic ultrasound (EUS) performance requires a combination of technical, cognitive, and non-technical skills. Direct observation assessment tools can be employed to enhance learning and ascertain clinical competence; however, there is a need to systematically evaluate validity evidence supporting their use. We aimed to evaluate the validity evidence of competency assessment tools for EUS and examine their educational utility.
View Article and Find Full Text PDFDevelopment and Validation of a Survival Prediction Model for Patients with Pancreatic Cancer.
Clin Transl Gastroenterol
December 2024
Article Synopsis
- A survival prognostication model was developed for pancreatic ductal adenocarcinoma (PDAC) patients using clinical data, patient-reported symptoms, and treatment specifics to aid in their treatment decisions.
- The study analyzed data from 17,450 PDAC patients in Ontario over a 13-year period, finding significant predictors of survival, including tumor location, disease stage, hospitalizations, heart failure, and various pain and performance scores.
- The model demonstrated good predictive accuracy with a C index of 0.76, suggesting it could enhance shared decision-making between patients and healthcare providers regarding treatment options.
Article Synopsis
- The study focuses on developing guidelines for the safe use of fluoroscopy in gastrointestinal endoscopy, balancing its benefits with concerns about radiation exposure to patients and healthcare workers.
- A modified Delphi method was used, involving three rounds of surveys with 46 experts, resulting in 43 proposed statements, of which 31 achieved consensus and were prioritized across various categories such as Patient Safety and Staff Safety.
- The final consensus statements highlight the importance of education and safety measures, with a significant majority rated as high priority, aiming to enhance safety culture in healthcare settings while utilizing fluoroscopy.
Article Synopsis
- * Analyzing 30 studies with over 9,000 participants, results indicated that higher levels of postoperative pain were associated with an increased risk of POD, but there was low certainty in these findings, and there was very low certainty regarding the link between pain and POCD.
- * The study faced challenges due to methodological differences among the included studies, which complicated the pooling of data and assessment of evidence certainty, particularly for chronic postsurgical pain (CPSP) with POD or POCD.
Article Synopsis
- A study was conducted to assess the implementation of complex genomic sequencing (CGS) for advanced cancer patients, involving DNA testing and patient surveys to evaluate how CGS could influence their treatment.
- Out of the 199 patients tested, a significant number (63%) had findings that could impact their management, with 16% experiencing changes in therapy based on CGS results within six months.
- Patients generally felt satisfied with the CGS process, appreciating its potential benefits, although many overestimated the likelihood of their results affecting treatment; clinicians emphasized the importance of effective communication during the process.
Article Synopsis
- * Analysis of data from over 55,000 breast cancer patients showed that co-observation of variants in BRCA1, BRCA2, and PALB2 with other breast cancer genes occurred less frequently than expected, suggesting a potential correlation with pathogenicity.
- * The findings indicate that identifying a variant of uncertain significance alongside a known pathogenic variant supports evidence against the variant's pathogenicity, which could improve variant classification in clinical settings and for other genetic conditions.
Correction: Gill et al. Report from the 24th Annual Western Canadian Gastrointestinal Cancer Consensus Conference on Colorectal Cancer, Richmond, British Columbia, 28-29, October 2022. 2023, , 7964-7983.
Sharlene Gill Shahid Ahmed Brady Anderson Scott Berry Howard Lim Joao Paulo Solar Vasconcelos James Paul
Curr Oncol
June 2024
Article Synopsis
- Karen Mulder was omitted as an author in the initial release of the publication.
- This exclusion raises questions about authorship and recognition of contributions in academic work.
- The situation highlights the importance of proper crediting in research and the potential impact on the individuals involved.
Article Synopsis
- * A multicenter clinical trial called PLAN will study the effects of intravenous lidocaine versus a placebo in over 1,600 patients undergoing breast cancer surgery, measuring outcomes like persistent pain incidence and opioid use at various time points post-surgery.
- * If successful, the trial could establish lidocaine infusion as a standard treatment to reduce chronic pain and opioid reliance in breast cancer patients, potentially lowering healthcare costs and improving overall patient well-being.
Article Synopsis
- The study aims to establish accurate age-related penetrance figures for various cancer types linked to pathogenic germline variants, which is essential for effective clinical management and variant classification.
- Researchers used full pedigree data from 146 families across Australia, Spain, and the U.S. to estimate cancer penetrance, adjusting for biases and background cancer risks.
- The findings reveal high cumulative risks for core cancers associated with Li-Fraumeni syndrome and identify significant lifetime risks for additional cancers, helping refine clinical recommendations for individuals with these pathogenic variants.