Publications by authors named "James P Logue"
Article Synopsis
- The emergence of new SARS-CoV-2 variants threatens the effectiveness of immunity from previous infections or vaccinations.
- To tackle this issue, the NIH launched the SARS-CoV-2 Assessment of Viral Evolution (SAVE) program for real-time assessment of variant risks that might impact transmission and vaccine efficacy.
- The program focuses on gathering and analyzing data on emerging variants and their effects on immunity, using animal models, while also addressing future challenges in monitoring rapidly evolving viruses.
Zaire ebolavirus (EBOV) causes Ebola virus disease (EVD), which carries a fatality rate between 25% and 90% in humans. Liver pathology is a hallmark of terminal EVD; however, little is known about temporal disease progression. We used multiplexed fluorescent immunohistochemistry and in situ hybridization in combination with whole slide imaging and image analysis (IA) to quantitatively characterize temporospatial signatures of viral and host factors as related to EBOV pathogenesis.
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