Single-nucleotide Polymorphism of CTLA-4 (rs5742909) in Correlation with Schizophrenia Risk Factor.

Background: Cytotoxic T protein lymphocyte antigen-4 (CTLA-4) plays a key role in regulating the T-cell system, where occurrence of disturbances in the system seen by imbalances in Th1 and Th2 levels is believed to be one of the etiologies of schizophrenia. Single-nucleotide polymorphisms (SNPs) at rs5742909 in the -4 gene (C→T) might affect the expression level of CTLA-4 protein.

Aims And Objectives: The aim of this study was to determine the genotype distribution of the gene (rs5742909) in patients with schizophrenia at Rumah Sakit Jiwa Prof.

Polymorphism of Gene rs120074175 Is Not Associated with Risk Factors of Schizophrenia.

Context: Polymorphism on tryptophan hydroxylase 2 () gene rs120074175 can cause the synthesis of neurotransmitter serotonin in the brain to reduce up to 80%. Reduced serotonin in the brain can cause dopamine release to occur continuously. Excess dopamine in the brain may cause positive symptom of schizophrenia.