Publications by authors named "James O'Mahony"

This work assessed four varieties of quinoa leaves, two grown in Ireland and two in Chile, as endogenous sources of soluble proteins. The four leaf protein extracts, obtained using mild extraction conditions, had different nutrient compositions, with protein contents ranging from 53 ± 2 to 63 ± 2 %. The protein extract from variety quinoa Zeno (Ireland) presented the lowest content of chlorophyll, 0.

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Bovine milk proteins account for 10% of the global protein supply, which justifies the importance of thoroughly understanding their digestive processes. Extensive research on digestion is being conducted both and . However, interpretations and comparisons across different studies require a thorough understanding of the methodologies used.

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Background: Identification of groups at a high risk of gastric cancer could facilitate targeted screening in countries with a low gastric cancer incidence. Our aim was to identify such high-risk groups based on individual-level population data on migration history and socioeconomic status (SES) in the Netherlands.

Methods: In this retrospective cohort study, patient data from the Netherlands Cancer Registry were linked to demographic data of Statistics Netherlands in the period 2010 to 2022.

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Background & Aims: Whether gastric cancer (GC) precursor lesions progress to invasive cancer at similar rates globally remains unknown. We conducted a systematic review and meta-analysis to determine the progression of precursor lesions to GC in countries with low versus medium/high incidence.

Methods: We searched relevant databases for studies reporting the progression of endoscopically confirmed precursor lesions to GC.

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Article Synopsis
  • Lactoferrin (LF) and osteopontin (OPN) are milk proteins that can form complexes, which were studied for their effects on infant digestion and health.
  • Pre-clinical models showed that these complexes enhance LF's protective qualities during digestion and improve its impact on gut health.
  • In a neonatal rodent model, LF-OPN coacervation promoted better bone structure and increased stiffness, indicating potential benefits for bone development.
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Racial and ethnic disparities in incidence and mortality are well documented for many types of cancer. As a result, there is understandable policy and clinical interest in race- and ethnicity-based clinical screening guidelines to address cancer health disparities. Despite the theoretical benefits, such proposals do not typically address associated ethical considerations.

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Purpose: There are several factors that negatively impact the well-being of those working in the screen industry. Consequently, the need to introduce Well-being Coordinators has been identified. This study explored the experiences of participants who undertook a Well-being Coordination course tailored for the screen sector.

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Article Synopsis
  • - The study aimed to understand the global prevalence of precursor lesions for gastric cancer (GC), focusing on conditions like atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia across different regions with varying GC risks.
  • - The analysis of 166 qualifying studies found that the global prevalence rates were 25.4% for AG, 16.2% for IM, and 2.0% for dysplasia, with higher rates in countries with medium and high GC incidence, especially among those infected with Helicobacter pylori.
  • - The findings indicate that a significant number of individuals with precursor lesions may not show symptoms, highlighting that symptomatic evaluation alone might not effectively identify those at risk for GC,
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Whey protein denaturation and aggregation have long been areas of research interest to the dairy industry, having significant implications for process performance and final product functionality and quality. As such, a significant number of analytical techniques have been developed or adapted to assess and characterize levels of whey protein denaturation and aggregation, to either maximize processing efficiency or create products with enhanced functionality (both technological and biological). This review aims to collate and critique these approaches based on their analytical principles and outline their application for the assessment of denaturation and aggregation.

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In response to global challenges such as climate change and food insecurity, plant proteins have gained interest. Among these, lentils have emerged as a promising source of proteins due to their good nutritional profile and sustainability considerations. However, their widespread use in food products has been impeded by limited solubility.

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The World Health Organisation states that more than 350 million people experience depression globally. The phenomenological changes in individuals experiencing depression are profound Phenomenological research can further researchers' and clinicians' understanding of this experience. This study aimed to gain a phenomenological understanding of how individuals with depression understood and made sense of their experiences.

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WHAT IS KNOWN ON THE SUBJECT?: Mental health recovery is acknowledged as a process of transformation and a way of living a meaningful life despite the presence of mental ill-health. Experiencing hope has been articulated as intrinsic to service users experience of a meaningful life. The social construction of mental illness and stigma are recognised as barriers to experiencing hope.

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Processing temperature has a significant influence on the composition and functionality of the resulting streams following microfiltration (MF) of skim milk. In this study, MF and diafiltration (DF) were performed at 4 or 50°C to produce β-casein (β-CN)-depleted and nondepleted (i.e.

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Objectives: This study aimed to assess whether recently proposed alternatives to the quality-adjusted life-year (QALY), intended to address concerns about discrimination, are suitable for informing resource allocation decisions.

Methods: We consider 2 alternatives to the QALY: the health years in total (HYT), recently proposed by Basu et al, and the equal value of life-years gained (evLYG), currently used by the Institute for Clinical and Economic Review. For completeness we also consider unweighted life-years (LYs).

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Telehealth is an emerging approach that uses technology to provide healthcare remotely. Recent publications have outlined the importance of supporting the transition to self-management of adolescents with allergic conditions. However, no synthesis of the evidence base on the use and impact of telehealth interventions for this purpose has been conducted to date.

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Sweet and, to a lesser extent, acid whey protein ingredients can be used for the formulation of infant nutritional products. Unlike acid whey, sweet whey contains caseinomacropeptide (CMP), a heat-stable peptide liberated from κ-casein during cheese and rennet casein manufacture. Four protein systems-sweet whey (SW) and acid whey (AW), with or without standardization for CMP protein content-were added to skim milk (50/50, wt/wt) and unheated or heated to 85 or 110°C.

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Article Synopsis
  • * Using a flexible synthetic control method, results showed significant reductions in gastric cancer mortality in South Korea but unclear benefits for Japan, where the program's effectiveness is questioned.
  • * The findings suggest South Korea’s screening program is effective, while Japan's results may indicate potential bias, providing insights for other countries considering similar public health initiatives.
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Objectives: To examine trends in rates of self-harm among emergency department (ED) presenting older adults in Ireland over a 13-year period.

Design: Population-based study using data from the National Self-Harm Registry Ireland.

Setting: National hospital EDs.

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Article Synopsis
  • Health technology assessment (HTA) relies on value-based reasoning that combines ethical considerations with empirical evidence, but its current language is unclear and inconsistent, leading to transparency issues.
  • A group of 24 researchers proposes a new framework to clarify key terms and types of normative commitments in HTA, improving the decision-making process for practitioners and policymakers.
  • The framework aims to foster better public reasoning and accountability, ensuring that health decisions are made transparently and can be ethically evaluated.
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Background: Identification of individuals at elevated risk can improve cancer screening programmes by permitting risk-adjusted screening intensities. Previous work introduced a prognostic model using sex, age and two preceding faecal haemoglobin concentrations to predict the risk of colorectal cancer (CRC) in the next screening round. Using data of 3 screening rounds, this model attained an area under the receiver-operating-characteristic curve (AUC) of 0.

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Engaging with children and adolescents in mental health settings who are exhibiting behaviours that challenge can often result in the use of seclusion, restraint and coercive practices. It is recognised that more therapeutic ways to engage this population are needed, adopting trauma informed interventions may provide a solution. The aim of this systematic review is to synthesize the evidence in relation to the effect of trauma-informed interventions on coercive practices in child and adolescent residential settings.

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Introduction: Self-care is essential for nurses' wellbeing, with stress posing a major barrier. Research into self-care is often absorbed into studies of burnout or resilience. Understanding lived experiences of influences on nurses' self-care practices is essential.

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