Autism and EEG phase reset: deficient GABA mediated inhibition in thalamo-cortical circuits.

The purpose of this study was to explore the relationship between electroencephalogram (EEG) phase reset in autism spectrum disorder (ASD) subjects as compared to age matched control subjects. The EEG was recorded from 19 scalp locations from 54 autistic subjects and 241 control subjects ranging in age from 2.6 years to 11 years.

Low natural killer cell cytotoxic activity in autism: the role of glutathione, IL-2 and IL-15.

Although many articles have reported immune abnormalities in autism, NK cell activity has only been examined in one study of 31 patients, of whom 12 were found to have reduced NK activity. The mechanism behind this low NK cell activity was not explored. For this reason, we explored the measurement of NK cell activity in 1027 blood samples from autistic children obtained from ten clinics and compared the results to 113 healthy controls.

Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.

Background: Autism is a complex neurodevelopmental disorder that usually presents in early childhood and that is thought to be influenced by genetic and environmental factors. Although abnormal metabolism of methionine and homocysteine has been associated with other neurologic diseases, these pathways have not been evaluated in persons with autism.

Objective: The purpose of this study was to evaluate plasma concentrations of metabolites in the methionine transmethylation and transsulfuration pathways in children diagnosed with autism.