Activation of fluoride anion as nucleophile in water with data-guided surfactant selection.

A principal component was developed for 91 commonly accessible surfactants for use in surfactant-enabled organic reactions in water, an important approach for sustainable chemical processes. This map was built using 22 experimental and theoretical descriptors relevant to the physicochemical nature of these surfactant-enabled reactions, and advanced principal component analysis algorithms. It is comprised of all classes of surfactants, cationic, anionic, zwitterionic and neutral surfactants, including designer surfactants.