Transparency, trustworthiness and usefulness in pre-eclampsia randomised controlled trials in the last three decades.

Objectives: Over the last decades, there has been a rising number of randomised controlled trials (RCTs) on pre-eclampsia. We investigated pre-eclampsia RCTs between 1987 and 2021 and reported on trustworthiness, risk of biases, p-values, transparency, and usefulness.

Methods: We searched PubMed for RCTs containing "pre-eclampsia" or "hypertensive disorders of pregnancy" in the title between 1987 and 2021.

Blastocyst quality and reproductive and perinatal outcomes: a multinational multicentre observational study.

Study Question: Does the transfer of single low-grade blastocysts result in acceptable reproductive and perinatal outcomes compared to the transfer of single good-grade blastocysts?

Summary Answer: The transfer of single low-grade blastocysts resulted in a reduced live birth rate of around 30% (14% for very low-grade blastocysts) compared to 44% for single good-grade blastocysts, but does not lead to more adverse perinatal outcomes.

What Is Known Already: It is known that low-grade blastocysts can result in live births. However, the current studies are limited by relatively small sample sizes and single-centre designs.

What happens to abnormally fertilized embryos? A scoping review.

A dearth of evidence exists on embryos derived from oocytes without two pronuclei (2PN) or 'normal fertilization', i.e. embryos arising from non-pronuclear oocytes (0PN), mono-pronuclear oocytes (1PN) and tri-pronuclear oocytes (3PN).

Should we look for a low-grade threshold for blastocyst transfer? A scoping review.

Embryo quality is a key determinant of the success of IVF. Although the focus has been on selecting the best embryo for transfer, the classification of low-grade blastocysts (LGB) in existing scoring systems has received less attention. This is worrisome; embryo freezing allows optimal use of all created embryos, thus maximizing the cumulative live birth rate, which is arguably the most important outcome for infertile couples.

Vehicle Exhaust Remote Sensing Device Method to Screen Vehicles for Evaporative Running Loss Emissions.

Vehicle hydrocarbon (HC) emissions can be emitted from either tailpipe or nontailpipe locations, and understanding their fleet apportionment is important for a successful air pollution policy. Vehicles initially misidentified as having elevated tailpipe HC emissions first indicated that roadside exhaust sensors could detect the presence of evaporative HC emissions as increased noise in the HC/carbon dioxide (CO) correlation measurement. The 90th percentile of the largest residual of the HC/CO correlation is defined as a running loss index (RLI) for each measurement.

Preimplantation genetic testing for aneuploidy: are we examining the correct outcomes?

Questions continue to be raised regarding the benefit of genetic assessment of embryos prior to transfer in IVF, specifically with regards to preimplantation genetic testing for aneuploidy (PGT-A). To evaluate and quantify these concerns, we appraised the most recent (2012-2019) randomized controlled trials on the topic. Only two of these six studies listed cumulative live birth rates per started cycle, with both eliciting a statistically non-significant result.

Reproducible research practices and transparency in reproductive endocrinology and infertility articles.

Objective: To analyse the published literature in reproductive endocrinology and infertility (REI) to examine the transparency and the use of reproducible research practices of the scientific literature and to identify possible avenues for improvement.

Design: Meta-epidemiologic study. We examined the first 20 consecutive full-text original articles presenting primary data from five REI-specific journals for 2013 and for 2018, and eligible REI articles published in 2013-2018 in five high-impact general journals.

The quality and utility of research in ectopic pregnancy in the last three decades: An analysis of the published literature.

Objective: Ectopic pregnancy is a potentially life-threatening health problem that affects fertility and generates a significant economic burden. Optimal management, including when to choose methotrexate, and whether to do salpingectomy or salpingostomy, is still unclear. This study aimed to assess the quality and utility of research on ectopic pregnancy in the last three decades.

Preimplantation Genetic Testing for Aneuploidy: A Review.

Importance: Preimplantation genetic testing for aneuploidy (PGT-A) has undergone many technical developments over recent years, including changes in biopsy timings, methodology, and genetic analysis techniques. The evidence surrounding the efficaciousness of PGT-A is sporadic and inconsistent; as such, significant doubt and concern remain regarding its widespread implementation.

Objective: This review seeks to describe the historical development of PGT-A and to analyze and summarize the current published literature.

Quality of evidence on pre-eclampsia in the last three decades: An analysis of published literature.

Objectives: In recent years, there has been an increasing amount of information published on pre-eclampsia. We analyzed trends in pre-eclampsia literature between 1997 and 2016 and reported on the quality and utility of randomized controlled trials (RCTs) between 1987 and 2016.

Methods: We searched PubMed for all articles containing "pre-eclampsia" or "hypertensive disorders of pregnancy" in the title between 1997 and 2016 for the general literature and between 1987 and 2016 for RCTs.

Subsidizing PGD: The Moral Case for Funding Genetic Selection.

Preimplantation genetic diagnosis (PGD) allows the detection of genetic abnormalities in embryos produced through in vitro fertilization (IVF). Current funding models in Australia provide governmental subsidies for couples undergoing IVF, but do not extend to PGD. There are strong reasons for publicly funding PGD that follow from the moral principles of autonomy, beneficence and justice for both parents and children.