Publications by authors named "James L Ludtke"
Mol Ther Nucleic Acids
September 2012
Article Synopsis
- Bispecific antibodies (bsAbs) were developed to deliver small interfering RNA (siRNA) specifically to cancer cells by targeting tumor antigens while also binding to digoxigenin (Dig).
- The bsAb-siRNA complexes effectively internalized into cells, but the release of siRNA into the cytoplasm was initially insufficient for mRNA knockdown.
- To enhance delivery and achieve effective mRNA knockdown, the siRNA was formulated into nanoparticles, enabling targeted siRNA delivery in a variety of cell types and showing promising results in tumor models in mice.
