Publications by authors named "James Key"
Objective: Dedifferentiated endometrial carcinoma (DDEC) characterized by SWItch/Sucrose Non-Fermentable (SWI/SNF) complex inactivation is a highly aggressive type of endometrial cancer without effective systemic therapy options. Its uncommon nature and aggressive disease trajectory pose significant challenges for therapeutic progress. To address this obstacle, we focused on developing preclinical models tailored to this tumor type and established patient tumor-derived three-dimensional (3D) spheroid models of DDEC.
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- The study aimed to investigate if detectable upper respiratory infections (URIs) during adenoidectomy/adenotonsillectomy lead to more complications or unexpected hospital admissions in children.
- A total of 164 pediatric patients were analyzed, with 82.9% testing positive for URIs, but there were no significant differences in postoperative outcomes between those with and without detectable infections.
- The findings suggest that routine preoperative URI testing is unnecessary, as having a recent URI does not increase risks during or after outpatient surgeries in healthy children.
The concept of applying a lens to the cornea as a refractive appliance was first proposed in the early 19th century. By 1888, glass scleral lenses for the correction of optical defects and irregularities were manufactured and used. New materials, especially soft hydrogel lenses and rigid gas-permeable lenses, became available in the 20th century and allowed comfortable contact lenses to be made in any design needed.
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