Clinical effectiveness of an online psychoeducational and psychotherapeutic programme for caregivers of children newly diagnosed as autistic: a parallel, assessor-masked, randomised controlled trial in the UK (REACH-ASD).

Background: Caregivers of autistic children experience particularly poor levels of mental health and increased caregiving complexities. Proactive post-diagnostic family support is recommended but is inconsistently implemented, largely not evidence based, and does not directly address caregiver mental health. This study aimed to test the clinical effectiveness of the Empower-Autism programme plus treatment as usual versus the usual local post-diagnostic psychoeducation offer plus treatment as usual on caregiver mental health at the 52-week follow-up.

Telelactation Services and Breastfeeding by Race and Ethnicity: A Randomized Clinical Trial.

Importance: There are substantial disparities in breastfeeding rates by race and ethnicity. Telelactation services that connect parents to lactation consultants via video are increasingly available and may reduce inequities in breastfeeding support; however, there is limited evidence on effectiveness.

Objective: To assess the impact of video telelactation services on breastfeeding duration and exclusivity across a racially and ethnically diverse population of parents.

Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study.

Objective: Determine the association of walking cadence to incident and worsening knee pain and physical function over 2 years in adults with or at risk for knee OA.

Design: Participants from the Multicenter Osteoarthritis study were included.Cadence was measured using a GAITRite walkway.

Hematologic dynamics during pregnancy and their association with obstetric complications: a retrospective cohort study.

Objectives: Pregnancy alters hematologic state as measured by complete blood counts (CBC), but the longitudinal changes in CBC indices that define healthy pregnancies are not well established. Our objectives were (1) to define gestational age-specific reference intervals for CBCs and their longitudinal changes in a large United States-based cohort and (2) to use these reference intervals to examine associations between extreme CBC values and changes and risk of obstetric complications.

Design: Retrospective cohort study including electronic health record-based discovery and validation cohorts.

Clinical characteristics and economic impact of acute hospitalisations due to bronchiectasis exacerbations among adult Indigenous Australians in the Top End Northern Territory.

This cross-sectional study assessed the clinical and economic costs (Inpatient Activity Database) associated with hospitalisations due to bronchiectasis exacerbations among adult indigenous patients in the Top End, Northern Territory. Twenty case episodes from 15 indigenous patients with a mean age of 51.8 ± 12.

Geothermal Arsenic Threats to Intensive Groundwater Utilization in an Arid Basin.

Groundwater quality is critical for safe drinking water and irrigation supplies but can be threatened by geogenic toxins that are difficult to predict. In the arid, high desert San Luis Valley (SLV), Colorado, a groundwater basin serves as the primary water supply with observed arsenic concentrations exceeding the maximum contaminant level (MCL) of 10 μg/L set by the U.S.

Primary Care Utilization Within 1 Year After a Facilitated Postpartum-to-Primary Care Transition.

Objective: To evaluate the effect of a behavioral science-informed intervention designed to facilitate postpartum-to-primary care transitions on primary care visits and screenings within 1 year postpartum for individuals with chronic conditions or pregnancy conditions with long-term health risks.

Methods: This was a planned secondary analysis of a randomized controlled trial of a behavioral science-informed intervention designed to increase primary care practitioner (PCP) visits within 4 months postpartum compared with routine care. The intervention included default PCP visit scheduling with nudge reminders and use of tailored language.

Evaluating the efficacy of vatiquinone in preclinical models of Leigh syndrome and GPX4 deficiency.

Background: Genetic mitochondrial diseases are a major challenge in modern medicine. These impact ~ 1:4,000 individuals and there are currently no effective therapies. Leigh syndrome is the most common pediatric presentation of mitochondrial disease.

Investigation of the frequency and selected prevalence factors of equid alphaherpesvirus 4 viremia in horses with acute onset of fever and respiratory signs.

Equid alphaherpesvirus 4 (EqAHV4; , ; equine rhinopneumonitis virus) has seldom been associated with complications such as abortion and myeloencephalopathy, given the low tendency of this virus to induce viremia. We investigated the frequency of EqAHV4 viremia in horses with fever and respiratory signs. Case selection included all equids with EqAHV4 quantitative real-time PCR (qPCR)-positive nasal secretions (defined as EqAHV4 qPCR-positive cases) submitted to a diagnostic laboratory.

Single-cell and Spatial Transcriptomics Illuminate Bat Immunity and Barrier Tissue Evolution.

Bats have adapted to pathogens through diverse mechanisms, including increased resistance-rapid pathogen elimination, and tolerance-limiting tissue damage following infection. In the Egyptian fruit bat (an important model in comparative immunology), several mechanisms conferring disease tolerance were discovered, but mechanisms underpinning resistance remain poorly understood. Previous studies on other species suggested that the elevated basal expression of innate immune genes may lead to increased resistance to infection.

Continuous cell type diversification throughout the embryonic and postnatal mouse visual cortex development.

The mammalian cortex is composed of a highly diverse set of cell types and develops through a series of temporally regulated events that build out the cell type and circuit foundation for cortical function. The mechanisms underlying the development of different cell types remain elusive. Single-cell transcriptomics provides the capacity to systematically study cell types across the entire temporal range of cortical development.

Patriarchy, Fertility and Excess Female Child Mortality in India.

Research investigating association between patriarchy and demographic behavior is limited in India. The only study on this subject utilized 1981 Indian Census data to examine associations between patriarchy and fertility. We examined the association of patriarchy, measured using India Patriarchy Index (IPI), with total fertility rate (TFR) and excess female child mortality in India.

Evaluating the outcomes of Australia's first all-age public hospital Sport and Exercise Medicine Outpatient Clinic: a retrospective cross-sectional study.

Objectives This study aimed to evaluate the outcomes of Australia's first public hospital all-age Sport and Exercise Medicine Outpatient Clinic (SEMOC). Methods A retrospective cross-sectional study of patients referred to and reviewed in the SEMOC, during a study period from March to October 2023, was performed. Outcomes were the number of appointments, number of patients reviewed, proportion reviewed within Queensland Health recommended timeframes, patient satisfaction, proportion of Aboriginal and Torres Strait Islander patients, and the rurality of the patients based on the Modified Monash Model of remoteness.

The experience of youth on the waitlist for gender-affirming care in Manitoba.

Objectives: Waitlist times for adolescents to be seen for initial assessment for gender-affirming hormone therapy in Manitoba, Canada are often 2 years. The purpose of this study was to understand the experiences of waitlisted youth and to assess the impact of social work contact for accessing relevant resources.

Methods: A qualitative, semi-structured interview study was conducted.

Relationship Between 1,5 Anhydroglucitol, Glycemia, and Breastfeeding During Pregnancy and Postpartum: A Pilot Study.

Background: Assessments for hyperglycemia are vital to pregnancy and postpartum (PP) care, but gold-standard oral glucose tolerance tests (OGTTs) are burdensome. We examined changes in 1,5 anhydroglucitol (1,5AG) levels during gestation and PP and assessed for associations with other measures of glycemia.

Study Design: Pregnant participants (n = 50) in the Study of Pregnancy Regulation of Insulin and Glucose cohort underwent OGTTs at a mean of 13 weeks ([visit 1 (V1)] and 26 weeks [visit 2 (V2)] of gestation and PP.

Real-World Social Reward Processes are Linked to Momentary Positive Affect in Adolescent Girls.

Positive peer interactions are critical for adolescent development and well-being. Showing little interest in interacting socially with peers and/or extracting little reward from positive peer interactions can be markers of social anhedonia, which impacts many youths, especially girls, with social anxiety and depressive disorders. Reduced interest or reward in peer interactions may contribute to social anxiety and depression in girls through effects on positive affect (PA), though associations between social anhedonia and momentary PA have yet to be tested.

The Role of Neural Sensitivity to Social Evaluation in Understanding "for Whom" Social Media Use May Impact Emotional Health During Adolescence.

There is much interest in the role of social media (SM) in the current mental health crisis among teens. In this review, we focus on the question of "for whom" SM experiences have the strongest impact on emotional health, considering neural sensitivity to social evaluation as a potential vulnerability factor that makes youth more susceptible to the effects of SM. We first present behavioral evidence showing that sensitivity to social evaluation moderates the link between SM use and emotional health in youth.

Telehealth use and receipt of recommended services within one-year postpartum.

Introduction: In obstetrics, telehealth is widely used in the provision of prenatal and postpartum care. The objective was to compare the utilization of commonly recommended services after delivery among individuals receiving telehealth versus in-person postpartum care.

Study Design: We performed a retrospective cohort study of individuals receiving postpartum care at a single institution between 1 July 2020 and 30 June 2023.

A challenge to identity: Identity processing style and moral injury.

Moral injury is a potentially deleterious mental health outcome that can result from exposure to morally challenging events. Treatment of moral injury is currently hindered by incomplete understanding of its underlying mechanisms. Theories of adaptation posit that maintaining a coherent sense of self while realigning one's sense of self with reality aids in adaptation following a disruptive life event.

Evaluating Renal Disease in Pediatric-Onset Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Disease Course, Outcomes, and Predictors of Outcome.

Objective: We aimed to study the disease course, outcomes, and predictors of outcome in pediatric-onset antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) affecting the kidneys.

Methods: Patients eligible for this study had a diagnosis of granulomatosis with polyangiitis (GPA), microscopic polyangiitis, or ANCA-positive pauci-immune glomerulonephritis, were 18 years or younger at diagnosis, had renal disease defined by biopsy or dialysis dependence, and had clinical data at diagnosis and at either 12 or 24 months. Ambispective data from A Registry for Children with Vasculitis/Pediatric Vasculitis Initiative Registry was used.

Single-cell integration reveals metaplasia in inflammatory gut diseases.

The gastrointestinal tract is a multi-organ system crucial for efficient nutrient uptake and barrier immunity. Advances in genomics and a surge in gastrointestinal diseases has fuelled efforts to catalogue cells constituting gastrointestinal tissues in health and disease. Here we present systematic integration of 25 single-cell RNA sequencing datasets spanning the entire healthy gastrointestinal tract in development and in adulthood.

The impact of group antenatal care on newborns: Results of a cluster randomized control trial in Eastern Region, Ghana.

Background: Maternal recognition of neonatal danger signs following birth is a strong predictor of care-seeking for newborn illness, which increases the odds of newborn survival. However, research suggests that maternal knowledge of newborn danger signs is low. Similarly, maternal knowledge of optimal newborn care practices has also been shown to be low.

Association Between Particulate Matter Pollutants and Ophthalmology Visits for Ocular Surface Irritation and Allergy.

Background: The World Health Organization has declared climate change to be "the single biggest health threat facing humanity", yet there are limited studies on the impact of climate change-related air pollution on ocular health.

Objective: To explore associations between ocular surface irritation and allergy-related daily outpatient office visits with daily ambient particulate matter (PM) levels in the Denver Metropolitan Area.

Methods: Daily visit counts of ophthalmology outpatient offices were obtained from an academic health center (October 1, 2015 to January 27, 2023).

The private market for antimicrobials: an exploration of two selected mining and frontier areas of Guyana.

Objective: To identify challenges that may raise pathogens' resistance to antimicrobial drugs by exploring the private market for antimicrobials in two selected mining and frontier areas of Guyana.

Methods: The private sector supply was mapped by approaching all authorized pharmacies and informal outlets, e.g.