Effect of Orthognathic Surgery On Pulp Blood Flow and Pulp Sensibility: A Prospective Control Trial.

Introduction: Orthognathic surgery has the potential to compromise the vitality of the teeth. This paper aims to assess changes in pulp blood flow (PBF) and pulp sensibility (PS) of the anterior dentition following orthognathic surgery and to assess the influence of the proximity of the surgical osteotomy on the PBF and/or PS.

Methods: Twenty-six patients undergoing orthognathic surgery (Le Fort I or bilateral sagittal split osteotomy [BSSO]) were compared to sixteen control patients treated by fixed appliances only using Laser Doppler flowmeter (LDF) and thermal testing (CO2 snow).

Optimizing the use of panoramic radiography for determining the position of impacted permanent maxillary canines.

The purpose of this research was to test the reliability of a modified magnification method for determining the position of an impacted canine from a single panoramic radiograph. This retrospective study evaluated 114 panoramic radiographs showing 136 impacted maxillary canines. The widths of the impacted canines, contralateral erupted canines, and ipsilateral maxillary incisors were measured, and ratios for the canine-incisor index (CII) and canine-canine index (CCI) were calculated.

Candidate genes for obstructive sleep apnea in non-syndromic children with craniofacial dysmorphisms - a narrative review.

Pediatric obstructive sleep apnea (POSA) is a complex disease with multifactorial etiopathogenesis. The presence of craniofacial dysmorphisms influencing the patency of the upper airway is considered a risk factor for POSA development. The craniofacial features associated with sleep-related breathing disorders (SRBD) - craniosynostosis, retrognathia and micrognathia, midface and maxillary hypoplasia - have high heritability and, in a less severe form, could be also found in non-syndromic children suffering from POSA.

An evaluation of gingival phenotype and thickness as determined by indirect and direct methods.

Objectives: To evaluate gingival phenotype (GP) and thickness (GT) using visual, probing, and ultrasound (US) methods and to assess the accuracy and consistency of clinicians to visually identify GP.

Materials And Methods: The GP and GT of maxillary and mandibular anterior teeth in 29 orthodontic patients (mean age 25 ± 7.5 years) were assessed using probing and US by a single examiner.

Effect of craniofacial morphology on gingival parameters of mandibular incisors.

Objectives: To investigate the association between the width of keratinized gingiva (WKG), gingival phenotype (GP), and gingival thickness (GT) with craniofacial morphology in sagittal and vertical dimensions.

Materials And Methods: WKG, GP, and GT of mandibular anterior teeth in 177 preorthodontic patients (mean age 18.38 ± 5.

Accuracy of mandibular repositioning surgery using new technology: Computer-aided design and manufacturing customized surgical cutting guides and fixation plates.

Introduction: Recent 3-dimensional technology advancements have resulted in new techniques to improve the accuracy of intraoperative transfer. This study aimed to validate the accuracy of computer-aided design and manufacturing (CAD-CAM) customized surgical cutting guides and fixation plates on mandibular repositioning surgery performed in isolation or combined with simultaneous maxillary repositioning surgery.

Methods: Sixty patients who underwent mandibular advancement surgery by the same surgeon were retrospectively evaluated by 3-dimensional surface-based superimposition.

Analysis of pretreatment factors associated with stability in early class III treatment.

Background: The purpose of this study was to identify pretreatment factors associated with the stability of early class III treatment, since most orthodontists start the treatment with their uncertain hypotheses and/or predictions. Subjects consisted of 75 patients with a class III skeletal relationship (ANB < 2° and overjet < 0 mm) who had been consecutively treated with rapid maxillary expansion and facemask and followed until their second phase treatment. The patients were divided into two groups according to whether they showed relapse in follow-up.

Heredity, Genetics and Orthodontics - How Much Has This Research Really Helped?

Uncovering the genetic factors that correlate with a clinical deviation of previously unknown etiology helps to diminish the unknown variation influencing the phenotype. Clinical studies, particularly those that consider the effects of an appliance or treatment regimen on growth, need to be a part of these types of genetic investigations in the future. While the day-to-day utilization of "testing" for genetic factors is not ready for practice yet, genetic testing for monogenic traits such as Primary Failure of Eruption (PFE) and Class III malocclusion is showing more promise as knowledge and technology advances.

Bone Density and Dental External Apical Root Resorption.

When orthodontic patients desire shorter treatment times with aesthetic results and long-term stability, it is important for the orthodontist to understand the potential limitations and problems that may arise during standard and/or technology-assisted accelerated treatment. Bone density plays an important role in facilitating orthodontic tooth movement (OTM), such that reductions in bone density can significantly increase movement velocity. Lifestyle, genetic background, environmental factors, and disease status all can influence a patients' overall health and bone density.

Aging, inflammation, immunity and periodontal disease.

The increased prevalence and severity of periodontal disease have long been associated with aging, such that this oral condition affects the majority of the adult population over 50 years of age. Although the immune system is a critical component for maintaining health, aging can be characterized by quantitative and qualitative modifications of the immune system. This process, termed 'immunosenescence', is a progressive modification of the immune system that leads to greater susceptibility to infections, neoplasia and autoimmunity, presumably reflecting the prolonged antigenic stimulation and/or stress responses that occur across the lifespan.

Comparison of BMI, AHI, and apolipoprotein E ε4 (APOE-ε4) alleles among sleep apnea patients with different skeletal classifications.

Study Objectives: This case-control study investigated whether variations within the APOE-ε gene were associated with having a convex facial profile (skeletal Class II) compared to exhibiting a straight or concave facial profile (Class I or Class III) among patients with obstructive sleep apnea (OSA). Associations between the apnea-hypopnea index (AHI) and body mass index (BMI) scores for these OSA patients were also examined in the context of facial profile.

Method: OSA patients with an AHI ≥ 15 were recruited from a sleep clinic and classified by facial and dental occlusal relationships based on a profile facial analysis, lateral photographs, and dental examination.

Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects.

Bacterial adherence to the acquired dental pellicle, important in dental caries (caries), is mediated by receptor-adhesins such as salivary agglutinin binding to antigen I/II (I/II). Ten selected I/II epitopes were chosen to determine their reactivity to human salivary IgA. Previous studies suggested that a specific HLA biomarker group (HLA-DRB1*04) may have differential influence of immune responses to I/II.

Genetics and non-syndromic facial growth.

Just as pediatricians and endocrinologists are interested in understanding statural growth patterns and the prediction of adult height, pediatric dentists, orthodontists, and oral/maxillofacial surgeons need to be knowledgeable about a patient's facial growth patterns to effectively treat them. Some variations in facial growth have been clinically associated with a poor esthetic self-image, malocclusion formation and the development of physical and/or functional deformity. To understand how different genetic factors influence growth and development patterns, scientists and clinicians study developmental sequences, malformations and syndromes.

Association between CYP19A1 genotype and pubertal sagittal jaw growth.

Introduction: Sagittal jaw growth is influenced during puberty by a ratio of androgens and estrogens. The CYP19A1 (formerly CYP19) gene encodes the cytochrome P450 enzyme aromatase (estrogen synthetase), which converts testosterone to estrogen. Genetic variations including single nucleotide polymorphisms might regulate CYP19A1 gene expression or the function of the aromatase protein and thus influence sagittal jaw growth.

Evaluation of retention protocols among members of the American Association of Orthodontists in the United States.

Introduction: Little research has been conducted to evaluate protocols and trends in orthodontic retention. The purpose of this study was to identify the general retention protocols used by orthodontists in the United States. Additionally, our goal was to identify trends in these orthodontic retention protocols by evaluating how they have changed over the past 5 years and how they might continue to change in the next 5 years.

Dental maturity of Caucasian children in the Indianapolis area.

Purpose: The purpose of this study was to compare chronologic and dental age using Demirjian's method.

Methods: Two hundred and fifty-seven panoramic radiographs of healthy 5- to 17.5-year-old Caucasian children in the Indianapolis area were evaluated using Demirjian's 7 tooth method.

Clinical outcomes for patients finished with the SureSmile™ method compared with conventional fixed orthodontic therapy.

Objective: Utilize American Board of Orthodontics (ABO) cast/radiographic evaluation (CRE) to compare a series of 63 consecutive patients, finished with manual wire bending (conventional) treatment, vs a subsequent series of 69 consecutive patients, finished by the same orthodontist using the SureSmile™ (SS) method.

Materials And Methods: Records of 132 nonextraction patients were scored by a calibrated examiner blinded to treatment mode. Age and discrepancy index (DI) between groups were compared by t-tests.

Orthodontic mechanotransduction and the role of the P2X7 receptor.

Introduction: The P2X7 receptor plays a crucial role in bone biology and inflammation. Its main function is to promote necrotic tissue metabolism by ensuring a normal acute-phase inflammatory response. We used a mouse model to describe and compare orthodontic mechanotransduction in wild-type and P2X7 knock-out mice.

Comparison of the Bolton Standards to longitudinal cephalograms superimposed on the occipital condyle (I-point).

Objective: To compare traditional superimposition on sella turcica and the anterior cranial base (SACB) to superimposition referenced at the occipital condyle (I-point) for demonstrating craniofacial growth and development.

Materials And Methods: Tracings for ages 8, 10, 12, 15 and 18 were chosen from the Bolton Standards of Dentofacial Developmental Growth to compare superimposition with the traditional longitudinal reference at SACB (anterior curvature of sella turcica and anterior cranial base) to reference at I-point on the antero-inferior contour of the occipital condyles in norma lateralis. The serial tracings were superimposed using both the sagittal and postero-anterior (PA) tracings.

Inheritance of susceptibility to root resorption associated with orthodontic force in mice.

Introduction: External apical root resorption (EARR) is an unwanted sequelae of orthodontic treatment. Genetic factors account for approximately 64% of the EARR variation in humans. Inbred mice offer a model to control the environmental factors and genetic heterogeneity that complicate human genetic studies.

Tooth positioner effects on occlusal contacts and treatment outcomes.

Objective: To determine if an increase in tooth contacts is the principal effect of tooth positioner wear.

Materials And Methods: Patient charts from a consecutive series were reviewed until a sample of 100 cases that used a tooth positioner was obtained. One hundred control cases were randomly selected from patients treated at the same period.

Three-dimensional mechanical environment of orthodontic tooth movement and root resorption.

Introduction: The tension-compression theory of bone mechanotransduction is ubiquitous in orthodontics. However, partly due to deficiencies in the characterization of the mechanical environment, there is no consensus on the mechanisms that link stimuli to root resorption and bone response. In this study, we analyzed the predominant directions of tension and compression in the alveolar structures.

A comprehensive analysis of normal variation and disease-causing mutations in the human DSPP gene.

Within nine dentin dysplasia (DD) (type II) and dentinogenesis imperfecta (type II and III) patient/families, seven have 1 of 4 net -1 deletions within the approximately 2-kb coding repeat domain of the DSPP gene while the remaining two patients have splice-site mutations. All frameshift mutations are predicted to change the highly soluble DSPP protein into proteins with long hydrophobic amino acid repeats that could interfere with processing of normal DSPP and/or other secreted matrix proteins. We propose that all previously reported missense, nonsense, and splice-site DSPP mutations (all associated with exons 2 and 3) result in dominant phenotypes due to disruption of signal peptide-processing and/or related biochemical events that also result in interference with protein processing.

Treatment complexity index for assessing the relationship of treatment duration and outcomes in a graduate orthodontics clinic.

Introduction: Clinical cases completed by the Indiana University School of Dentistry (IUSD) graduating orthodontic classes of 2004, 2005, and 2006 were assessed to determine factors that affect orthodontic treatment duration.

Methods: The sample consisted of 455 consecutively finished patients who received comprehensive treatment in the full permanent dentition. They included optimally finished and prematurely terminated (early debond) patients.

Treatment outcomes in a graduate orthodontic clinic for cases defined by the American Board of Orthodontics malocclusion categories.

Introduction: The American Board of Orthodontics (ABO) discrepancy index (DI) quantifies the severity of a malocclusion. The ABO objective grading system (OGS) assesses the quality of orthodontic finishing. Indiana University's comprehensive clinical assessment (CCA) supplements the OGS to provide an instrument to determine clinical outcomes.