Mice with a heterozygous Lrp6 deletion have impaired fracture healing.

Bone fracture non-unions, the failure of a fracture to heal, occur in 10%-20% of fractures and are a costly and debilitating clinical problem. The Wnt/β-catenin pathway is critical in bone development and fracture healing. Polymorphisms of linking low-density lipoprotein receptor-related protein 6 (LRP6), a Wnt-binding receptor, have been associated with decreased bone mineral density and fragility fractures, although this remains controversial.

Biomechanical evaluation of fracture fixation constructs using a variable-angle locked periprosthetic femur plate system.

Background: In the United States there are more than 230,000 total hip replacements annually, and periprosthetic femoral fractures occur in 0.1-4.5% of those patients.

Mice lacking pten in osteoblasts have improved intramembranous and late endochondral fracture healing.

The failure of an osseous fracture to heal (development of a non-union) is a common and debilitating clinical problem. Mice lacking the tumor suppressor Pten in osteoblasts have dramatic and progressive increases in bone volume and density throughout life. Since fracture healing is a recapitulation of bone development, we investigated the process of fracture healing in mice lacking Pten in osteoblasts (Ocn-cre(tg/+;)Pten(flox/flox) ).

Bilateral patellar component shear failure of highly cross-linked polyethylene components: report of a case and laboratory analysis of failure mechanisms.

A case of bilateral patellar component failure due to fatigue fracture of the all-polyethylene fixation pegs in a highly cross-linked ultra-high-molecular-weight polyethylene design is presented. To recreate this failure mode, a novel test method was developed to investigate the effects of peg orientation and cement technique on patella fatigue strength under cyclic compression and shear loading. Patellar peg orientation had a minor effect on shear strength, whereas lack of cement in the backside patellar groove had a substantial effect.

SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease.

The study of rare human genetic disorders has often led to some of the most significant advances in biomedical research. One such example was the body of work that resulted in the identification of the Low Density Lipoprotein-Related Protein (LRP5) as a key regulator of bone mass. Point mutations were identified that encoded forms of LRP5 associated with very high bone mass (HBM).

Improved fatigue life of acrylic bone cements reinforced with zirconia fibers.

Poly(methyl methacrylate) (PMMA) bone cements have a long and successful history of use for implant fixation, but suffer from a relatively low fracture and fatigue resistance which can result in failure of the cement and the implant. Fiber or particulate reinforcement has been used to improve mechanical properties, but typically at the expense of the pre-cured cement viscosity, which is critical for successful integration with peri-implant bone tissue. Therefore, the objective of this study was to investigate the effects of zirconia fiber reinforcement on the fatigue life of acrylic bone cements while maintaining a relatively low pre-cured cement viscosity.

Patellofemoral interactions in walking, stair ascent, and stair descent using a virtual patella model.

Restoration of normal patella kinematics is an important clinical outcome of total knee arthroplasty. Failure of the patella within total knee systems has been documented and, upon occurrence, often necessitates revision surgery. It is thus important to understand patella mechanics following implantation, subject to load states that are typically realized during walking and other gaits.

Static and fatigue mechanical characterizations of variable diameter fibers reinforced bone cement.

Fibers can be used to improve the mechanical properties of bone cement for the long-term stability of hip prostheses. However, debonding of the fibers from the matrix due to the poor fiber/matrix interface is a major failure mechanism for such fiber reinforced bone cements. In this study, a novel fiber (variable diameter fibers or VDFs) technology for reinforced bone cement was studied to overcome the interface problem of short-fiber composites.

The effect of entrapped bone particles on the surface morphology and wear of polyethylene.

Clinically retrieved highly cross-linked ultrahigh molecular weight polyethylene (HXPE) acetabular liners have demonstrated scratching, whereas conventional ultrahigh-molecular-weight polyethylene (UHMWPE) implants show a smoother surface early after implantation. In the present study, the potential of bone particles and soft tissues, rather than cement, to scratch the articular surface of HXPE and UHMWPE (gamma radiated) acetabular components was evaluated; multiple bone particles located at the articular surface for 3600 simulated walking cycles replicated the scratches observed on retrieved implants. By remelting, these scratches were confirmed to be due to plastic deformation of the polyethylene, not wear.

Preparation and mechanical characterization of a PNIPA hydrogel composite.

A poly (N-isopropylacrylamide) (PNIPA) hydrogel was synthesized by free radical polymerization and reinforced with a polyurethane foam to make a hydrogel composite. The temperature dependence of the elastic modulus of the PNIPA hydrogel and the composite due to volume phase transition was found using a uniaxial compression test, and the swelling property was investigated using an equilibrium swelling ratio experiment. The gel composite preserves the ability to undergo the volume phase transition and its elastic modulus has strong temperature dependence.

A comparison of mechanical properties derived from multiple skeletal sites in mice.

Laboratory mice provide a versatile experimental model for studies of skeletal biomechanics. In order to determine the strength of the mouse skeleton, mechanical testing has been performed on a variety of bones using several procedures. Because of differences in testing methods, the data from previous studies are not comparable.