Publications by authors named "James J Crawford"

Synopsis of recent research by authors named "James J Crawford"

  • - James J Crawford's recent research primarily focuses on innovative strategies in drug discovery, including the development of DNA-encoded libraries (DELs) aimed at synthesizing diverse and efficient libraries for hit identification in medicinal chemistry.
  • - His work also addresses critical challenges in antibiotic development against multidrug-resistant bacteria by optimizing arylomycin derivatives for enhanced efficacy, especially targeting Gram-negative pathogens.
  • - Additionally, Crawford emphasizes the importance of structure-based drug design and metabolic stability, investigating inhibitors for significant pathways like NF-κB signaling and offering insights into gut-restricted therapeutics, thereby advancing targeted treatment options with reduced systemic exposure.

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