Synopsis of recent research by authors named "James J Crawford"
- James J Crawford's recent research primarily focuses on innovative strategies in drug discovery, including the development of DNA-encoded libraries (DELs) aimed at synthesizing diverse and efficient libraries for hit identification in medicinal chemistry.
- His work also addresses critical challenges in antibiotic development against multidrug-resistant bacteria by optimizing arylomycin derivatives for enhanced efficacy, especially targeting Gram-negative pathogens.
- Additionally, Crawford emphasizes the importance of structure-based drug design and metabolic stability, investigating inhibitors for significant pathways like NF-κB signaling and offering insights into gut-restricted therapeutics, thereby advancing targeted treatment options with reduced systemic exposure.
