Interactive effects between extreme temperatures and PM on cause-specific mortality in thirteen U.S. states.

The extent and robustness of the interaction between exposures to heat and ambient PM is unclear and little is known of the interaction between exposures to cold and ambient PM. Clarifying these interactions, if any, is crucial due to the omnipresence of PM in the atmosphere and increasing scope and frequency of extreme temperature events. To investigate both of these interactions, we merged 6 073 575 individual-level mortality records from thirteen states spanning seventeen years with 1 km daily PM predictions from sophisticated prediction model and 1 km meteorology from Daymet V4.

Grouped mixtures of air pollutants and seasonal temperature anomalies and cardiovascular hospitalizations among U.S. Residents.

Background: Air pollution is a recognized risk factor for cardiovascular disease (CVD). Temperature is also linked to CVD, with a primary focus on acute effects. Despite the close relationship between air pollution and temperature, their health effects are often examined separately, potentially overlooking their synergistic effects.

Validating the Modified McGill Thyroid Nodule Score for Assessment of Preoperative Risk of Pediatric Thyroid Malignancy.

Objective: The McGill Thyroid Nodule Score (MTNS) is a preoperative tool used to predict the risk for well-differentiated thyroid cancer in adults. It was developed by a multidisciplinary team using established evidence-based risk factors for thyroid cancer. The modified McGill Thyroid Nodule Score (mMTNS) was developed to predict malignancy risk in children.

Extramural US Federal Research Grants For Health Outcomes Associated With Climate Change Inadequate, Too Narrow In Focus.

Climate change causes and exacerbates disease, creates and worsens health disparities, disrupts health care delivery, and imposes a significant disease burden in the US and globally. Critical knowledge gaps hinder an evidence-based response and are perpetuated by scarce federal research funds. We identified and described extramural US federal research funding (that is, grants provided to organizations and institutions outside of federal agencies) that both addressed health outcomes associated with climate change and was awarded between 2010 and 2020.

Ultimate Black Hole Recoil: What is the Maximum High-Energy Collision Kick?

We performed a series of 1381 full numerical simulations of high energy collision of black holes to search for the maximum recoil velocity after their merger. We consider equal mass binaries with opposite spins pointing along their orbital plane and perform a search of spin orientations, impact parameters, and initial linear momenta to find the maximum recoil for a given spin magnitude s. This spin sequence for s=0.

Additive effects of 10-year exposures to PM and NO and primary cancer incidence in American older adults.

Unlabelled: Epidemiologic evidence on the relationships between air pollution and the risks of primary cancers other than lung cancer remained largely lacking. We aimed to examine associations of 10-year exposures to fine particulate matter (PM) and nitrogen dioxide (NO) with risks of breast, prostate, colorectal, and endometrial cancers.

Methods: For each cancer, we constructed a separate cohort among the national Medicare beneficiaries during 2000 to 2016.

Seasonal Temperature Variability and Mortality in the Medicare Population.

Background: Seasonal temperature variability remains understudied and may be modified by climate change. Most temperature-mortality studies examine short-term exposures using time-series data. These studies are limited by regional adaptation, short-term mortality displacement, and an inability to observe longer-term relationships in temperature and mortality.

Weighting of risk factors for low birth weight: a linked routine data cohort study in Wales, UK.

Objective: Globally, 20 million children are born with a birth weight below 2500 g every year, which is considered as a low birthweight (LBW) baby. This study investigates the contribution of modifiable risk factors in a nationally representative Welsh e-cohort of children and their mothers to inform opportunities to reduce LBW prevalence.

Design: A longitudinal cohort study based on anonymously linked, routinely collected multiple administrative data sets.

Patching of the Inferior Vena Cava Following Lateral Venorrhaphy in Penetrating Traumatic Injury.

Penetrating injury to the inferior vena cava (IVC) is associated with high morbidity and mortality. Luminal narrowing can occur following lateral venorrhaphy and can lead to future morbidity. This case report discusses the success of patch repair following lateral venorrhaphy in two trauma patients.

Autoimmune gene expression profiling of fingerstick whole blood in Chronic Fatigue Syndrome.

Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating condition that can lead to severe impairment of physical, psychological, cognitive, social, and occupational functions. The cause of ME/CFS remains incompletely understood. There is no clinical diagnostic test for ME/CFS.

MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape.

MLL rearrangements produce fusion oncoproteins that drive leukemia development, but the direct effects of MLL-fusion inactivation remain poorly defined. We designed models with degradable MLL::AF9 where treatment with small molecules induces rapid degradation. We leveraged the kinetics of this system to identify a core subset of MLL::AF9 target genes where MLL::AF9 degradation induces changes in transcriptional elongation within 15 minutes.

Telehealth in Pediatric Surgical Subspecialties: Rapid Adoption in the Setting of COVID-19.

Telehealth has evolved over the past several decades to address varying medical needs. Most recently, it has been widely utilized as a result of the COVID-19 pandemic. Most previous studies have not performed in-depth analyses of patient satisfaction with telehealth technologies.

Exploring the Small Mass Ratio Binary Black Hole Merger via Zeno's Dichotomy Approach.

We perform a sequence of binary black hole simulations with increasingly small mass ratios, reaching to a 128:1 binary that displays 13 orbits before merger. Based on a detailed convergence study of the q=m_{1}/m_{2}=1/15 nonspinning case, we apply additional mesh refinement levels around the smaller hole horizon [30] to reach successively the q=1/32, q=1/64, and q=1/128 cases. Roughly a linear computational resources scaling with 1/q is observed on eight-nodes simulations.

Whole-Exome Sequencing of Syndromic Adrenocortical Carcinoma Reveals Distinct Mutational Profile From Sporadic ACC.

Next-generation sequencing has provided genetic profiles of a large number of sporadic adrenocortical carcinomas (ACCs), but the applicability of these results to ACC cases associated with tumor predisposition syndromes is unclear. Although the germline features of these syndromes have been well described, the somatic mutational landscape of the tumors they give rise to is less clear. Our group obtained germline and tumor tissue from a pediatric patient who developed ACC during her first year of life, which was treated successfully.

A Critical Appraisal of the July Effect: Evaluating Complications Following Pancreaticoduodenectomy.

Background: Reports of higher rates of medical errors in the month of July have generated concern regarding major surgery at academic institutions early in the yearly promotion cycle. This study was designed to evaluate perioperative outcomes in patients undergoing pancreaticoduodenectomy (PD) at different times of the year.

Materials And Methods: Outcomes were retrospectively evaluated for patients treated in July versus the rest of the year and in the first quarter (July-September) versus the remaining quarters.

Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis.

Objective: We recently reported that curcumin supplementation in a metabolically (i.e., Western diet [WD]) and chemically (i.

Pediatric intussusception in Uganda: differences in management and outcomes with high-income countries.

Purpose: In high-income countries the presentation and treatment of intussusception is relatively rapid, and most cases are correctable with radiographically-guided reduction. In low-income countries, many delays affect outcomes and surgical intervention is required. This study characterizes the burden and outcome of pediatric intussusception in Uganda.

Best Buy in Public Health or Luxury Expense?: The Cost-effectiveness of a Pediatric Operating Room in Uganda From the Societal Perspective.

Objective: To determine the cost-effectiveness of building and maintaining a dedicated pediatric operating room (OR) in Uganda from the societal perspective.

Background: Despite the heavy burden of pediatric surgical disease in low-income countries, definitive treatment is limited as surgical infrastructure is inadequate to meet the need, leading to preventable morbidity and mortality in children.

Methods: In this economic model, we used a decision tree template to compare the intervention of a dedicated pediatric OR in Uganda for a year versus the absence of a pediatric OR.

Prediction of Postoperative Surgical Risk: A Needs Assessment for a Medical Student Curriculum.

Objective: Medical students' abilities to predict postoperative complications and death are unknown. We hypothesize that medical students will lack confidence in determining surgical risk and will significantly overestimate surgical risk for post-operative morbidities and mortality.

Design: Participants were invited to participate in an electronic, anonymous survey to assess their ability to predict surgical risk.

Author Correction: Soy protein supplementation is not androgenic or estrogenic in college-aged men when combined with resistance exercise training.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

Soy protein supplementation is not androgenic or estrogenic in college-aged men when combined with resistance exercise training.

It is currently unclear as to whether sex hormones are significantly affected by soy or whey protein consumption. Additionally, estrogenic signaling may be potentiated via soy protein supplementation due to the presence of phytoestrogenic isoflavones. Limited also evidence suggests that whey protein supplementation may increase androgenic signaling.

Association of Lowering Default Pill Counts in Electronic Medical Record Systems With Postoperative Opioid Prescribing.

Importance: Reliance on prescription opioids for postprocedural analgesia has contributed to the opioid epidemic. With the implementation of electronic medical record (EMR) systems, there has been increasing use of computerized order entry systems for medication prescriptions, which is now more common than handwritten prescriptions. The EMR can autopopulate a default number of pills prescribed, and 1 potential method to alter prescriber behavior is to change the default number presented via the EMR system.