Publications by authors named "James Hastings"
Propofol is a commonly used general anesthetic agent which has been previously shown to enhance the inhibitory GABAergic transmission in the central nervous system. In addition to the GABAergic element, the excitatory transmission may be another central molecular site impacted by propofol. Increasing evidence implies that the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor represents an excitatory amino acid receptor subtype subjected to the regulation by propofol.
View Article and Find Full Text PDFThe purpose of the present study was to conduct a mixed-methods investigation of meaning-making appraisals generated from spinal cord injury survivors' narratives of their injury experience. The sample consisted of 79 participants from an urban midwestern Veterans Affairs facility. The study design was cross-sectional and incorporated semistructured, face-to-face interviews, taking approximately 1 hr to complete.
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- The study compared the effectiveness of ceftobiprole medocaril, vancomycin, daptomycin, and their combinations in treating infective endocarditis caused by MRSA and GISA in rats.
- Ceftobiprole medocaril showed the best results as a standalone treatment, significantly reducing bacterial counts in the infected heart and achieving higher rates of sterile vegetation than other treatments.
- Synergistic effects were observed when ceftobiprole was combined with vancomycin, suggesting that this combination therapy could be beneficial for treating these difficult-to-treat infections, indicating the need for further research.
Objective: To define the prevalence of testosterone deficiency in persons with chronic spinal cord injury (SCI) and to identify factors associated with this deficiency.
Design: Cross-sectional study.
Setting: A U.
Objective: To determine the prevalence of prostate cancer in patients with chronic spinal cord injury (SCI), with regard to the duration, level, and severity of injury.
Design: Retrospective chart review study.
Setting: Inpatient and outpatient Veterans Affairs spinal cord unit.
Objective: This study examined the influence of medical injury severity, perceived loss of physical functioning (conceptualized as physical resource loss), and global meaning making on psychological well-being among 79 veterans living with a spinal cord injury.
Measures: Structured interviews were completed to assess perceived loss of physical abilities using the Conservation of Resources-Evaluation and SF-36 Health Survey, global meaning making (Purpose in Life scale), and psychological well-being (Sense of Well-Being Inventory). Medical injury severity was calculated from medical records.