Publications by authors named "James H Ho"
Frequent attenders in the emergency department: A trainee perspective.
Emerg Med Australas
June 2021
Introduction: There have been concerns about prosthesis failure and the potential for systemic toxicity due to release of cobalt and chromium from metal-on-metal hip joint prostheses (MoM-HP). There is conflicting evidence on whether there is a correlation between higher cobalt and chromium concentrations and systemic toxicity.
Methods: We undertook a retrospective review of consecutive patients with MoM-HP referred for outpatient review in toxicology clinics in London, UK, and in the USA recorded in the Toxicology Investigators Consortium (ToxIC) Registry from June 2011 to June 2015.
Context: Synthetic cannabinoid receptor agonists are the largest group of new psychoactive substances reported in the last decade; in this study we investigated how commonly these drugs are found in patients presenting to the Emergency Department with acute recreational drug toxicity.
Methods: We conducted an observational cohort study enrolling consecutive adult patients presenting to an Emergency Department (ED) in London (UK) January-July 2015 (6 months) with acute recreational drug toxicity. Residual serum obtained from a serum sample taken as part of routine clinical care was analyzed using high-resolution accurate mass-spectrometry with liquid-chromatography (HRAM-LCMSMS).
Article Synopsis
- Synthetic Cannabinoid Receptor Agonists (SCRAs) are a rapidly evolving group of new psychoactive substances that pose challenges in predicting their harms in pre-clinical studies.
- A case involving a 19-year-old female revealed serious health effects, including seizures and hallucinations, after she consumed "cannabis tea" and LSD, which contained confirmed SCRAs (5FAKB-48 and 5F-PB-22).
- This case underscores the complexities in understanding SCRAs' toxicity, especially in patients with existing mental health conditions treated with medications like fluoxetine and citalopram.
Purpose: Ethylphenidate is a novel psychoactive substance that is an analogue of methylphenidate. This paper describes its availability, patterns of use, and acute effects.
Methods: Searches of the scientific and grey literature (publicly accessible Internet resources) were undertaken, using the keywords "Ethylphenidate", "Ethyl phenidate", "Ethyl phenyl(piperidin-2-yl)acetate", and "Nopaine", to identify information on the prevalence and patterns of use, desired effects, and toxicity of ethylphenidate.