Psychometrics of drift-diffusion model parameters derived from the Eriksen flanker task: Reliability and validity in two independent samples.

The flanker task is a widely used measure of cognitive control abilities. Drift-diffusion modeling of flanker task behavior can yield separable parameters of cognitive control-related subprocesses, but the parameters' psychometrics are not well-established. We examined the reliability and validity of four behavioral measures: (1) raw accuracy, (2) reaction time (RT) interference, (3) NIH Toolbox flanker score, and (4) two drift-diffusion model (DDM) parameters-drift rate and boundary separation-capturing evidence accumulation efficiency and speed-accuracy trade-off, respectively.

Lack of effect of methamphetamine on reward-related brain activity in healthy adults.

Introduction: Stimulant drugs are thought to alter processing of rewarding stimuli. However, the mechanisms by which they do this are not fully understood.

Method: In this study we used EEG to assess effects of single doses of methamphetamine (MA) on neural responses during anticipation and receipt of reward in healthy volunteers.

Electrophysiological evidence of mal-adaptation to error in remitted depression.

Identifying risk markers for major depressive disorder (MDD) that persist into remission is key to address MDD's high rate of recurrence. Central to MDD recurrence are the disorder's negative information processing biases, such as heightened responses to errors, which may subsequently impair abilities to monitor performance and adjust behaviors based on environmental demands. However, little is known regarding the neurophysiological correlates of post-error adaptation in depression.

Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity.

Renewed interest in classic psychedelics as treatments for psychiatric disorders warrants a deeper understanding of their neural mechanisms. Single, high doses of psychedelic drugs have shown promise in treating depressive disorders, perhaps by reversing deficits in reward processing in the brain. In addition, there are anecdotal reports that repeated ingestion of low doses of LSD, or "microdosing", improve mood, cognition, and feelings of wellbeing.

Δ9-THC reduces reward-related brain activity in healthy adults.

Rationale: Greater availability of cannabis in the USA has raised concerns about adverse effects of the drug, including possible amotivational states. Lack of motivation may be assessed by examining acute effects of cannabinoids on reward processing.

Objectives: This study examined single doses of delta-9-tetrahydrocannabinol (∆9-THC; 7.

Neural mechanisms of motor dysfunction in individuals at clinical high-risk for psychosis: Evidence for impairments in motor activation.

Motor abnormalities are a core feature of psychotic disorders observed from the premorbid period through chronic illness, suggesting motor dysfunction may reflect the pathophysiology of psychosis. Electrophysiology research in schizophrenia suggests impaired motor activation and preparation may underlie these motor abnormalities. Despite behavioral studies suggesting similar motor dysfunction in those at clinical high-risk (CHR) for psychosis, there have been no studies examining neural mechanisms of motor dysfunction in the CHR period, where research can inform pathophysiological and risk models.

Outcome valence and stimulus frequency affect neural responses to rewards and punishments.

The Reward-Positivity (RewP) is a frontocentral event-related potential elicited following reward and punishment feedback. Reinforcement learning theories propose the RewP reflects a reward prediction error that increases following more favorable (vs. unfavorable) outcomes.

DRD4 polymorphisms modulate reward positivity and P3a in a gambling task: Exploring a genetic basis for cultural learning.

Prior work shows that people respond more plastically to environmental influences, including cultural influences, if they carry the 7 or 2-repeat (7/2R) allelic variant of the dopamine D4 receptor gene (DRD4). The 7/2R carriers are thus more likely to endorse the norms and values of their culture. So far, however, mechanisms underlying this moderation of cultural acquisition by DRD4 are unclear.

Emotional content impacts how executive function ability relates to willingness to wait and to work for reward.

Research has demonstrated that better value-based decision making (e.g., waiting or working for rewards) relates to greater executive function (EF) ability.

Shifts in attentional scope modulate event-related potentials evoked by reward.

Emotions broaden or narrow the scope of attention in order to facilitate adaptive responses in threatening and rewarding contexts. In the current study, rather than asking how emotions influence attentional scope, we considered the possibility that the relationship between attentional breadth and emotion is bidirectional by asking whether shifts in attentional scope alter emotional processes using an event-related potential (ERP) paradigm. Participants (N = 30) completed a modified version of a Monetary Incentive Delay (MID) task, wherein their attention was either narrowed or broadened as they attempted to win rewards.

Reappraisal and suppression emotion-regulation tendencies differentially predict reward-responsivity and psychological well-being.

Individuals who suppress their emotions experience less positive emotions, worse relationships, and a reduced quality of life whereas those who tend to reappraise show an opposite pattern. Despite this divergent pattern, few have asked how the use of these emotion-regulation strategies relates to reward responsivity. We predicted that elevated suppression would be associated with blunted reward responsivity, whereas reappraisal would be associated with elevated reward responsivity.

Hypomania and depression associated with distinct neural activity for immediate and future rewards.

Bipolar spectrum and unipolar depressive disorders have been associated with distinct and opposite profiles of reward-related neural activity. These opposite profiles may reflect a differential preexisting vulnerability for both types of disorders. In support, recent ERP studies find that, following reward feedback, a larger reward positivity (RewP) is associated with greater vulnerability for bipolar spectrum disorders, whereas a smaller RewP is associated with greater vulnerability for depression.

Beyond the FRN: Broadening the time-course of EEG and ERP components implicated in reward processing.

Most reward-related electroencephalogram (EEG) studies focus exclusively on the feedback-related negativity (FRN, also known as feedback negativity or FN, medial-frontal negativity or MFN, feedback error-related negativity or fERN, and reward positivity or RewP). This component is usually measured approximately 200-300 ms post-feedback at a single electrode in the frontal-central area (e.g.

Suppression of error-preceding brain activity explains exaggerated error monitoring in females with worry.

Anxiety is consistently associated with hyperactive neural responses to errors. The majority of existing research has focused on a single marker of error-elicited brain activity-the error-related negativity (ERN), an event-related brain potential (ERP) elicited 50-100ms following an erroneous response. The ERN has accumulated growing interest for its use in clinical contexts as a potential biomarker and/or endophenotype.

Cultural shaping of neural responses: Feedback-related potentials vary with self-construal and face priming.

Previous work shows that when an image of a face is presented immediately prior to each trial of a speeded cognitive task (face-priming), the error-related negativity (ERN) is upregulated for Asians, but it is downregulated for Caucasians. These findings are consistent with the hypothesis that images of "generalized other" vary cross-culturally such that they evoke anxiety for Asians, whereas they serve as safety cues for Caucasians. Here, we tested whether the cross-cultural variation in the face-priming effect would be observed in a gambling paradigm.

Attention deficit hyperactivity disorder and the athlete: an American Medical Society for Sports Medicine position statement.

Attention deficit hyperactivity disorder (ADHD) is an important issue for the physician taking care of athletes since ADHD is common in the athletic population, and comorbid issues affect athletes of all ages. The health care provider taking care of athletes should be familiar with making the diagnosis of ADHD, the management of ADHD, and how treatment medications impact exercise and performance. In this statement, the term "Team Physician" is used in reference to all healthcare providers that take care of athletes.

An approach to the diagnosis and treatment of plantar fasciitis.

Plantar fasciitis is a painful condition affecting many athletes. Anatomic and biomechanical factors combined with overuse can contribute to its genesis. Correction of gait disturbances, changes in footwear, use of tension night splints, and stretching of tight calf and plantar tissues have all be proven to relieve symptoms.

Awareness of altitude sickness among visitors to a North American ski resort.

Objective: To quantify awareness of acute mountain sickness (AMS) in a sample of visitors to a North American ski resort and to identify strategies and interest for increasing knowledge of AMS in that population.

Methods: One hundred and thirty visitors to Big Sky Ski Resort, Montana, were surveyed. Demographic data were obtained.

Eating disorders among male athletes.

Eating disorders may affect some athletes at rates much greater than the general population. Among male athletes, eating disorders are on the rise. Studies show that males participating in sports in which leanness confers a competitive advantage may be at greater risk of eating disorders.

Misrepresentation of research citations by applicants to a primary care sports medicine fellowship program in the United States.

Objective: To determine the prevalence of misrepresentation of publications and national presentations claimed in applications to the Maine Medical Center (MMC) Primary Care Sports Medicine Fellowship Program from 2001 through 2004.

Design: A retrospective chart review study.

Setting: The Maine Medical Center Primary Care Sports Medicine Fellowship Program.