Comparison of 16 Pediatric Acute Respiratory Distress Syndrome-Associated Plasma Biomarkers With Changing Lung Injury Severity.

Objectives: Pediatric acute respiratory distress syndrome (PARDS) is a source of substantial morbidity and mortality in the PICU, and different plasma biomarkers have identified different PARDS and ARDS subgroups. We have a poor understanding of how these biomarkers change over time and with changing lung injuries. We sought to determine how biomarker levels change over PARDS course, whether they are correlated, and whether they are different in critically ill non-PARDS patients.

Long-Term Earth-Moon Evolution With High-Level Orbit and Ocean Tide Models.

Tides and Earth-Moon system evolution are coupled over geological time. Tidal energy dissipation on Earth slows rotation rate, increases obliquity, lunar orbit semi-major axis and eccentricity, and decreases lunar inclination. Tidal and core-mantle boundary dissipation within the Moon decrease inclination, eccentricity and semi-major axis.

Multi-omic characterization of pediatric ARDS via nasal brushings.

Rationale: While nasal brushing transcriptomics can identify disease subtypes in chronic pulmonary diseases, it is unknown whether this is true in pediatric acute respiratory distress syndrome (PARDS).

Objectives: Determine whether nasal transcriptomics and methylomics can identify clinically meaningful PARDS subgroups that reflect important pathobiological processes.

Methods: Nasal brushings and serum were collected on days 1, 3, 7, and 14 from control and PARDS subjects from two centers.

CPR Blitzkrieg: Training 500 High School Students in less than 48 hours.

BACKGROUND Many states, including Arkansas, require CPR training before high school graduation. METHODS We modified the American Heart Association's CPR in Schools curriculum to deliver CPR and AED training with maximal individual practice. RESULTS 520 students were trained over a two-day period at Little Rock Central High School.

Gravity field of the Orientale basin from the Gravity Recovery and Interior Laboratory Mission.

The Orientale basin is the youngest and best-preserved major impact structure on the Moon. We used the Gravity Recovery and Interior Laboratory (GRAIL) spacecraft to investigate the gravitational field of Orientale at 3- to 5-kilometer (km) horizontal resolution. A volume of at least (3.

Lunar impact basins revealed by Gravity Recovery and Interior Laboratory measurements.

Observations from the Gravity Recovery and Interior Laboratory (GRAIL) mission indicate a marked change in the gravitational signature of lunar impact structures at the morphological transition, with increasing diameter, from complex craters to peak-ring basins. At crater diameters larger than ~200 km, a central positive Bouguer anomaly is seen within the innermost peak ring, and an annular negative Bouguer anomaly extends outward from this ring to the outer topographic rim crest. These observations demonstrate that basin-forming impacts remove crustal materials from within the peak ring and thicken the crust between the peak ring and the outer rim crest.

The past and present Earth-Moon system: the speed of light stays steady as tides evolve.

Tides induce a semimajor axis rate of +38.08 ± 0.19 mm/yr, corresponding to an acceleration of the Moon's orbital mean longitude of -25.

Leveraging the national cyberinfrastructure for biomedical research.

In the USA, the national cyberinfrastructure refers to a system of research supercomputer and other IT facilities and the high speed networks that connect them. These resources have been heavily leveraged by scientists in disciplines such as high energy physics, astronomy, and climatology, but until recently they have been little used by biomedical researchers. We suggest that many of the 'Big Data' challenges facing the medical informatics community can be efficiently handled using national-scale cyberinfrastructure.

Gravity field of the Moon from the Gravity Recovery and Interior Laboratory (GRAIL) mission.

Spacecraft-to-spacecraft tracking observations from the Gravity Recovery and Interior Laboratory (GRAIL) have been used to construct a gravitational field of the Moon to spherical harmonic degree and order 420. The GRAIL field reveals features not previously resolved, including tectonic structures, volcanic landforms, basin rings, crater central peaks, and numerous simple craters. From degrees 80 through 300, over 98% of the gravitational signature is associated with topography, a result that reflects the preservation of crater relief in highly fractured crust.

The crust of the Moon as seen by GRAIL.

High-resolution gravity data obtained from the dual Gravity Recovery and Interior Laboratory (GRAIL) spacecraft show that the bulk density of the Moon's highlands crust is 2550 kilograms per cubic meter, substantially lower than generally assumed. When combined with remote sensing and sample data, this density implies an average crustal porosity of 12% to depths of at least a few kilometers. Lateral variations in crustal porosity correlate with the largest impact basins, whereas lateral variations in crustal density correlate with crustal composition.

Ancient igneous intrusions and early expansion of the Moon revealed by GRAIL gravity gradiometry.

The earliest history of the Moon is poorly preserved in the surface geologic record due to the high flux of impactors, but aspects of that history may be preserved in subsurface structures. Application of gravity gradiometry to observations by the Gravity Recovery and Interior Laboratory (GRAIL) mission results in the identification of a population of linear gravity anomalies with lengths of hundreds of kilometers. Inversion of the gravity anomalies indicates elongated positive-density anomalies that are interpreted to be ancient vertical tabular intrusions or dikes formed by magmatism in combination with extension of the lithosphere.

Progress in lunar laser ranging tests of relativistic gravity.

Analyses of laser ranges to the Moon provide increasingly stringent limits on any violation of the equivalence principle (EP); they also enable several very accurate tests of relativistic gravity. These analyses give an EP test of Delta(MG/MI)EP=(-1.0+/-1.