Publications by authors named "James G Merritt"
Article Synopsis
- PCORnet is a National Research Network funded by PCORI that uses standardized electronic health records and patient input to facilitate pragmatic health research across 79 health system sites.
- The network has evolved to include additional data sources such as commercial health plans and federal insurance claims, enhancing its ability to represent patient health and experiences more comprehensively.
- With amendments allowing the inclusion of economic outcomes in research, PCORnet's phase 3, starting in January 2022, aims to bolster economic patient-centered outcomes through improved data linkages and stakeholder engagement.
Article Synopsis
- A study explored how different doses of aspirin (81 mg vs 325 mg) affected health outcomes in patients with peripheral artery disease (PAD) and examined their involvement in a clinical trial.
- Results indicated that participants with PAD experienced significantly higher rates of serious health events like heart attacks and strokes, but higher aspirin doses did not offer any additional benefits.
- Additionally, patients with PAD showed lower rates of enrollment and internet engagement in the study, highlighting the need for tailored research and strategies to better involve these patients in clinical trials.
Background: The appropriate dose of aspirin to lower the risk of death, myocardial infarction, and stroke and to minimize major bleeding in patients with established atherosclerotic cardiovascular disease is a subject of controversy.
Methods: Using an open-label, pragmatic design, we randomly assigned patients with established atherosclerotic cardiovascular disease to a strategy of 81 mg or 325 mg of aspirin per day. The primary effectiveness outcome was a composite of death from any cause, hospitalization for myocardial infarction, or hospitalization for stroke, assessed in a time-to-event analysis.