Publications by authors named "James Emmett Herndon"
Clin Transl Oncol
March 2023
Article Synopsis
- Medulloblastoma, the most common malignant brain tumor in children, has four main molecular subgroups (WNT, SHH, Group 3, Group 4) and shows variable expression of the cell surface protein CD155, which is critical for the viral therapeutic agent PVSRIPO to enter cells.
- Research demonstrated that CD155 expression varies among medulloblastoma subgroups, with highest levels in the WNT subgroup and not significantly linked to patient survival outcomes.
- The study found that blocking CD155 led to increased cell death and reduced invasion and migration of tumor cells, suggesting its potential as a target for therapies like PVSRIPO and other CD155-blocking agents.
