Identifying low-risk chest pain in the emergency department without troponin testing: a validation study of the HE-MACS and HEAR risk scores.

Introduction: Patients presenting to EDs with chest pain of possible cardiac origin represent a substantial and challenging cohort to risk stratify. Scores such as HE-MACS (History and Electrocardiogram-only Manchester Acute Coronary Syndromes decision aid) and HEAR (History, ECG, Age, Risk factors) have been developed to stratify risk without the need for troponin testing. Validation of these scores remains limited.

Experimental study on the performances of second-harmonic dispersion interferometers at 10.6 µm and 1064 nm for plasma density measurements.

Two common-path interferometers based on and : (Nd:YAG) lasers are benchmarked with a two-arm microwave interferometer on a hydrogen plasma produced by an RF discharge and injected into a large magnetic-confinement vessel. The ∼10 line-integrated electron density is clearly measured in agreement by the interferometers. The frequency spectrum of the measured data is analyzed on the 20 kHz range for all interferometers and up to 600 kHz for the Nd:YAG laser-based interferometer.

Resistance to carbapenems and other antibiotics in found in seals indicates anthropogenic pollution.

Background: The beta-lactamase enzyme OXA-48 has spread widely in recent years in Enterobacteriaceae associated with man, disseminated primarily on incompatibility group L/M plasmids. OXA-48 confers resistance to carbapenems, important antimicrobials for treating highly resistant bacterial infections in humans. This enzyme has rarely been detected in bacteria from animals.

Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro.

Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured outside the body. The in vivo environment, particularly constant electromechanical stimulation, is fundamental to the regulation of cardiac structure and function. We investigated the role of electromechanical stimulation in preventing culture-induced dedifferentiation of adult cardiac tissue using rat, rabbit and human heart failure myocardial slices.

Has respiratory cryptosporidiosis spread to black grouse ?

Infection by was first confirmed in red grouse in northern England in 2010 and within three years spread to 48 per cent of moors. These form the last English stronghold for the rarer black grouse, and given the rapid spread of respiratory cryptosporidiosis among red grouse, concern has been expressed about possible infection. In 2010, the authors started screening black grouse for cryptosporidiosis in (1) dead birds taken for postmortem examination, (2) sample birds caught at night and (3) an observational study of birds attending leks.

Reference map for liquid chromatography-mass spectrometry-based quantitative proteomics.

The accurate mass and time (AMT) tag strategy has been recognized as a powerful tool for high-throughput analysis in liquid chromatography-mass spectrometry (LC-MS)-based proteomics. Due to the complexity of the human proteome, this strategy requires highly accurate mass measurements for confident identifications. We have developed a method of building a reference map that allows relaxed criteria for mass errors yet delivers high confidence for peptide identifications.

Dynamics of hyperthermal collisions of O(3P) with CO.

The dynamics of O(3P) + CO collisions at a hyperthermal collision energy near 80 kcal mol-1 have been studied with a crossed molecular beams experiment and with quasi-classical trajectory calculations on computed potential energy surfaces. In the experiment, a rotatable mass spectrometer detector was used to monitor inelastically and reactively scattered products as a function of velocity and scattering angle. From these data, center-of-mass (c.